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学科主题: 临床医学
题名:
Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients
作者: Yu, Jing1; Ren, Jun1; Di, Li-jun1; Song, Guo-hong1; Zhu, Yu-lin1; Zhang, Jie1; Liang, Xu1; Che, Li1; Jiang, Han-fang1; Jia, Jun1; Zhang, Chun-rong2
关键词: Docetaxel ; Granulocyte colony-stimulating factor (G-CSF) ; Mobilization ; Stem cell
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2011-03-01
DOI: 10.1007/s11670-011-0049-8
卷: 23, 期:1, 页:49-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEMATOPOIETIC PROGENITOR CELLS ; PHASE-III TRIAL ; G-CSF ; ADJUVANT CHEMOTHERAPY ; DOSE CHEMOTHERAPY ; RANDOMIZED-TRIAL ; COLLECTION ; PACLITAXEL ; SURVIVAL ; SUPPORT
英文摘要:

Objective: To evaluate the effectiveness and safety of the mobilization of peripheral blood hematopoietic stem cells by combining docetaxel with granulocyte colony-stimulating factor (G-CSF) in breast cancer patients.

Methods: A total of 57 breast cancer patients were treated with docetaxel 120 mg/m(2). When the white blood cell (WBC) count decreased to 1.0x10(9)/L, patients were given G-CSF 5 mu g/kg daily by subcutaneous injection until the end of apheresis. Peripheral blood mononuclear cells (MNC) were isolated by Cobe Spectra Apheresis System. The percentage of CD34(+) cell was assayed by flow cytometry.

Results: At a median 6 of days (range 3-8) after the administration of docetaxel, the median WBC count decreased to 1.08x10(9)/L (range 0.20-2.31). The median duration of G-CSF mobilization was 3 days (range 2-7). The MNC collection was conducted 8-12 days (median 10 days) after docetaxel treatment. The median MNC was 5.35x10(8)/kg (range 0.59-14.07), the median CD34(+) cell count was 2.43x10(6)/kg (range 0.16-16.69). The CD34(+) cell count was higher than 1.00x10(6)/kg in 47 of 57 cases (82.46%) and higher than 2.00x10(6)/kg in 36 cases (63.16%). The CD34(+) cell count was higher than 2.00x10(6)/kg in 27 collections (23.68%). The MNC count and the CD34(+) cell count were correlated with the bottom of WBC after docetaxel chemotherapy (r=0.364, 0.502, P=0.005, 0.000). The CD34(+) cell count was correlated with the MNC count (r=0.597, P=0.000). The mobilization and apheresis were well tolerated in all patients. Mild perioral numbness and numbness of hand or feet were observed in 3 cases. No serious adverse events were reported.

Conclusion: Mobilization of peripheral blood hematopoietic stem cell by combining docetaxel with G-CSF was effective and safety in breast cancer patients.

语种: 英语
所属项目编号: 2007-2053
项目资助者: Beijing Capital Development Foundation for Medical Sciences
WOS记录号: WOS:000290804200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67522
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Breast Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Transfus, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Yu, Jing,Ren, Jun,Di, Li-jun,et al. Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients[J]. CHINESE JOURNAL OF CANCER RESEARCH,2011,23(1):49-53.
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