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学科主题: 临床医学
题名:
Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway
作者: He, Gang1; Guo, Wei2; Lou, Zhiyuan2; Zhang, Hu2
关键词: Achyranthes bidentata saponins ; Bone marrow stromal cells ; Extracellular signal-related kinases (ERK) ; Osteogenic differentiation
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2014-09-01
DOI: 10.1007/s12013-014-9942-3
卷: 70, 期:1, 页:467-473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: OSTEOBLAST DIFFERENTIATION ; KINASE
英文摘要:

Achyranthes bidentata, is a herbal plant commonly used in the treatment of osteoporosis and bone nonunion in the Traditional Chinese Medicine. Saponins are the major compounds extracted from Achyranthes bidentata that have been shown to exert various pharmacological activities such as anti-inflammatory, antipyretic, antirheumatic, diuretic, and anti-osteoporosis. The Achyranthes bidentata saponins (ABS) were found to induce proliferation and differentiation in bone marrow stromal cells (BMSCs) as determined by the cell proliferation and alkaline phosphatase assays. Also, following the osteogenic induction, cells treated with ABS showed increased mRNA levels of rat bone morphogenetic protein-2, runt-related transcription factor 2, and osterix. Furthermore, ABS stimulated the activation of ERK as evidenced by increased phosphorylation of these proteins, which was blocked by an inhibitor of ERK (PD98059). Taken together, these results suggest that ABS stimulated osteogenic differentiation of BMSCs via activation of the ERK signaling pathway.

语种: 英语
WOS记录号: WOS:000340593200065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67524
Appears in Collections:北京大学第二临床医学院_骨关节科_期刊论文

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作者单位: 1.Zengcheng Peoples Hosp, Dept Orthopaed, Zengcheng City 511300, Guangdong, Peoples R China
2.Peking Univ, Dept Orthopaed, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
He, Gang,Guo, Wei,Lou, Zhiyuan,et al. Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,70(1):467-473.
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