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Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway
He, Gang1; Guo, Wei2; Lou, Zhiyuan2; Zhang, Hu2
关键词Achyranthes bidentata saponins Bone marrow stromal cells Extracellular signal-related kinases (ERK) Osteogenic differentiation
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2014-09-01
DOI10.1007/s12013-014-9942-3
70期:1页:467-473
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]OSTEOBLAST DIFFERENTIATION ; KINASE
英文摘要

Achyranthes bidentata, is a herbal plant commonly used in the treatment of osteoporosis and bone nonunion in the Traditional Chinese Medicine. Saponins are the major compounds extracted from Achyranthes bidentata that have been shown to exert various pharmacological activities such as anti-inflammatory, antipyretic, antirheumatic, diuretic, and anti-osteoporosis. The Achyranthes bidentata saponins (ABS) were found to induce proliferation and differentiation in bone marrow stromal cells (BMSCs) as determined by the cell proliferation and alkaline phosphatase assays. Also, following the osteogenic induction, cells treated with ABS showed increased mRNA levels of rat bone morphogenetic protein-2, runt-related transcription factor 2, and osterix. Furthermore, ABS stimulated the activation of ERK as evidenced by increased phosphorylation of these proteins, which was blocked by an inhibitor of ERK (PD98059). Taken together, these results suggest that ABS stimulated osteogenic differentiation of BMSCs via activation of the ERK signaling pathway.

语种英语
WOS记录号WOS:000340593200065
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67524
专题北京大学第二临床医学院_骨关节科
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Zengcheng Peoples Hosp, Dept Orthopaed, Zengcheng City 511300, Guangdong, Peoples R China
2.Peking Univ, Dept Orthopaed, Peoples Hosp, Beijing 100044, Peoples R China
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He, Gang,Guo, Wei,Lou, Zhiyuan,et al. Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,70(1):467-473.
APA He, Gang,Guo, Wei,Lou, Zhiyuan,&Zhang, Hu.(2014).Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway.CELL BIOCHEMISTRY AND BIOPHYSICS,70(1),467-473.
MLA He, Gang,et al."Achyranthes bidentata Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK MAPK Signaling Pathway".CELL BIOCHEMISTRY AND BIOPHYSICS 70.1(2014):467-473.
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