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Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study
Ananias, Hildo J. K.1; Yu, Zilin2; Hoving, Hilde D.1; Rosati, Stefano3; Dierckx, Ruth A.2; Wang, Fan4; Yan, Yongjun5; Chen, Xiaoyuan5; Pruim, Jan2,8; Lub-de Hooge, Marjolijn N.2,6; Helfrich, Wijnand7; Elsinga, Philip H.2; de Jong, Igle J.1
关键词Prostate cancer SPECT/CT Bombesin GRPR First-in-man
刊名NUCLEAR MEDICINE AND BIOLOGY
2013-10-01
DOI10.1016/j.nucmedbio.2013.05.009
40期:7页:933-938
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]GASTRIN-RELEASING-PEPTIDE ; RADIOLABELED BOMBESIN ANALOGS ; RECEPTOR ; IMMUNOREACTIVITY ; BIOPSIES
英文摘要

Rationale: The peptide bombesin (BBN) and its derivatives exhibit high binding affinity for the gastrin-releasing peptide receptor (GRPR), which is highly expressed in prostate cancer. We used the BBN-based radiopharmaceutical (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) (Tc-99m-HABBN) to perform a first-in-man clinical pilot study to evaluate the feasibility of Tc-99m-HABBN SPECT/CT for detection of prostate cancer in patients.

Methods: Eight patients with biopsy-proven prostate cancer who were scheduled for either radical prostatectomy or external beam radiotherapy underwent Tc-99m-HABBN scintigraphy and SPECT/CT prior to treatment. Serial blood samples were taken to assess blood radioactivity and to determine in vivo metabolic stability. Clinical parameters were measured and reported side effects, if present, were recorded. Prostate cancer specimens of all patients were immunohistochemically stained for GRPR.

Results: Tc-99m-HABBN was synthesized with high radiochemical yield, purity and specific activity. There were no significant changes in clinical parameters, and there were no adverse or subjective side effects. Low metabolic stability was observed, as less than 20% of Tc-99m-HABBN was intact after 30 min. Immunohistochemical staining for GRPR was observed in the prostate cancer specimens in all patients. Tc-99m-HABBN scintigraphy and SPECT/CT did not detect prostate cancer in patients with proven disease.

Conclusions: Tc-99m-HABBN SPECT/CT for visualization of prostate cancer is safe but hampered by an unexpected low in vivo metabolic stability in man. The difference between the excellent in vitro stability of Tc-99m-HABBN in human serum samples determined in our previous study regarding Tc-99m-HABBN and the low in vivo metabolic stability determined in this study, is striking. This issue warrants further study of peptide-based radiopharmaceuticals. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000324656100011
项目编号KWF 2008-4243 ; 08-02 ; 030-203
资助机构Dutch Cancer Society ; Dutch Urology Foundation (Stichting Urologie) ; Jan Komelis de Cock Stichting (J.K. de Cock Stichting) ; Center for Translational Molecular Medicine (project Prostate Cancer Molecular Medicine)
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67525
专题北京大学医药卫生分析中心
作者单位1.Peking Univ, Med Isotopes Res Ctr, Beijing, Peoples R China
2.Univ Groningen, Univ Med Ctr Groningen, Dept Urol, Groningen, Netherlands
3.Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands
4.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, Groningen, Netherlands
5.Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA
6.Univ Groningen, Univ Med Ctr Groningen, NL-9712 RB Groningen, Netherlands
7.Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Lab Translat Surg Oncol, Groningen, Netherlands
8.Univ Stellenbosch, Tygerberg Hosp, Dept Nucl Med, ZA-7600 Stellenbosch, South Africa
推荐引用方式
GB/T 7714
Ananias, Hildo J. K.,Yu, Zilin,Hoving, Hilde D.,et al. Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study[J]. NUCLEAR MEDICINE AND BIOLOGY,2013,40(7):933-938.
APA Ananias, Hildo J. K..,Yu, Zilin.,Hoving, Hilde D..,Rosati, Stefano.,Dierckx, Ruth A..,...&de Jong, Igle J..(2013).Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study.NUCLEAR MEDICINE AND BIOLOGY,40(7),933-938.
MLA Ananias, Hildo J. K.,et al."Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study".NUCLEAR MEDICINE AND BIOLOGY 40.7(2013):933-938.
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