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学科主题: 公共卫生
题名:
Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study
作者: Ananias, Hildo J. K.1; Yu, Zilin2; Hoving, Hilde D.1; Rosati, Stefano3; Dierckx, Ruth A.2; Wang, Fan4; Yan, Yongjun5; Chen, Xiaoyuan5; Pruim, Jan2,8; Lub-de Hooge, Marjolijn N.2,6; Helfrich, Wijnand7; Elsinga, Philip H.2; de Jong, Igle J.1
关键词: Prostate cancer ; SPECT/CT ; Bombesin ; GRPR ; First-in-man
刊名: NUCLEAR MEDICINE AND BIOLOGY
发表日期: 2013-10-01
DOI: 10.1016/j.nucmedbio.2013.05.009
卷: 40, 期:7, 页:933-938
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: GASTRIN-RELEASING-PEPTIDE ; RADIOLABELED BOMBESIN ANALOGS ; RECEPTOR ; IMMUNOREACTIVITY ; BIOPSIES
英文摘要:

Rationale: The peptide bombesin (BBN) and its derivatives exhibit high binding affinity for the gastrin-releasing peptide receptor (GRPR), which is highly expressed in prostate cancer. We used the BBN-based radiopharmaceutical (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) (Tc-99m-HABBN) to perform a first-in-man clinical pilot study to evaluate the feasibility of Tc-99m-HABBN SPECT/CT for detection of prostate cancer in patients.

Methods: Eight patients with biopsy-proven prostate cancer who were scheduled for either radical prostatectomy or external beam radiotherapy underwent Tc-99m-HABBN scintigraphy and SPECT/CT prior to treatment. Serial blood samples were taken to assess blood radioactivity and to determine in vivo metabolic stability. Clinical parameters were measured and reported side effects, if present, were recorded. Prostate cancer specimens of all patients were immunohistochemically stained for GRPR.

Results: Tc-99m-HABBN was synthesized with high radiochemical yield, purity and specific activity. There were no significant changes in clinical parameters, and there were no adverse or subjective side effects. Low metabolic stability was observed, as less than 20% of Tc-99m-HABBN was intact after 30 min. Immunohistochemical staining for GRPR was observed in the prostate cancer specimens in all patients. Tc-99m-HABBN scintigraphy and SPECT/CT did not detect prostate cancer in patients with proven disease.

Conclusions: Tc-99m-HABBN SPECT/CT for visualization of prostate cancer is safe but hampered by an unexpected low in vivo metabolic stability in man. The difference between the excellent in vitro stability of Tc-99m-HABBN in human serum samples determined in our previous study regarding Tc-99m-HABBN and the low in vivo metabolic stability determined in this study, is striking. This issue warrants further study of peptide-based radiopharmaceuticals. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: KWF 2008-4243 ; 08-02 ; 030-203
项目资助者: Dutch Cancer Society ; Dutch Urology Foundation (Stichting Urologie) ; Jan Komelis de Cock Stichting (J.K. de Cock Stichting) ; Center for Translational Molecular Medicine (project Prostate Cancer Molecular Medicine)
WOS记录号: WOS:000324656100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67525
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Peking Univ, Med Isotopes Res Ctr, Beijing, Peoples R China
2.Univ Groningen, Univ Med Ctr Groningen, Dept Urol, Groningen, Netherlands
3.Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands
4.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, Groningen, Netherlands
5.Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD USA
6.Univ Groningen, Univ Med Ctr Groningen, NL-9712 RB Groningen, Netherlands
7.Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Lab Translat Surg Oncol, Groningen, Netherlands
8.Univ Stellenbosch, Tygerberg Hosp, Dept Nucl Med, ZA-7600 Stellenbosch, South Africa

Recommended Citation:
Ananias, Hildo J. K.,Yu, Zilin,Hoving, Hilde D.,et al. Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients A first-in-man study[J]. NUCLEAR MEDICINE AND BIOLOGY,2013,40(7):933-938.
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