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学科主题: 精神卫生
题名:
Tardive dyskinesia in the treatment of schizophrenia: the findings of the Research on Asian Psychotropic Prescription Pattern (REAP) survey (2001-2009)
作者: Xiang, Y. -T.1,2; Wang, C. -Y.2; Si, T. -M.3; Lee, E. H. M.1; He, Y. -L.4; Ungvari, G. S.5; Chiu, H. F. K.1; Yang, S. -Y.6; Chong, M. -Y.7,8; Tan, C. -H.9; Kua, E. -H.9; Fujii, S.10; Sim, K.11; Yong, K. H.11; Trivedi, J. K.12; Chung, E. -K.13; Udomratn, P.14; Chee, K. -Y.15; Sartorius, N.16; Shinfuku, N.17
关键词: schizophrenia ; tardive dyskinesia ; ethnicity
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
发表日期: 2011-06-01
DOI: 10.5414/CP201505
卷: 49, 期:6, 页:382-387
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEALTH OUTCOMES SOHO ; RISK-FACTORS ; EAST-ASIA ; ANTIPSYCHOTIC TREATMENT ; PSYCHIATRIC-PATIENTS ; GENDER-DIFFERENCES ; NEGATIVE SYMPTOMS ; PREVALENCE ; CHINESE ; NEUROLEPTICS
英文摘要:

Objective: The aim of the study was to survey the frequency of tardive dyskinesia (TD) in patients with schizophrenia and its demographic and clinical correlates in selected Asian countries. Method: A total of 6,761 hospitalized schizophrenia patients in nine Asian countries and territories were examined from 2001 to 2009. TD was evaluated as "present" or "absent" according to the clinical judgment of experienced psychiatrists. The patients′ socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure. Results: The frequency of TD in the whole sample was 5.0% with wide variations between countries (0 - 14.9%). Multiple logistic regression analysis showed that the following variables were independently associated with TD: study time, study site, older age, male gender, more severe negative and extrapyramidal symptoms and less anticholinergic drugs. Conclusions: A generally low frequency of TD in Asian schizophrenia patients with inter-ethnic variations was recorded. It is unclear whether the low prevalence of TD compared with Western data is real or the result of it being insufficiently recognized.

语种: 英语
所属项目编号: 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Science Foundation ; Beijing Municipal Science and Technology Commission in China ; Chinese University of Hong Kong in Hong Kong ; Institute of Mental Health Research Grant in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000292222700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67527
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
2.Natl Seoul Hosp, Seoul, South Korea
3.Prince Songkla Univ, Hat Yai, Thailand
4.Univ Geneva, Geneva, Switzerland
5.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
6.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
7.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
8.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
9.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
10.Univ Notre Dame Australia Marian Ctr, Perth, WA, Australia
11.Taipei City Hosp, Taipei, Taiwan
12.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Guishan, Taiwan
13.Chang Gung Univ, Sch Med, Guishan, Taiwan
14.Natl Univ Singapore, Singapore 117548, Singapore
15.HITS, Kobe, Hyogo, Japan
16.Inst Mental Hlth, Bangkok View, Singapore
17.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia

Recommended Citation:
Xiang, Y. -T.,Wang, C. -Y.,Si, T. -M.,et al. Tardive dyskinesia in the treatment of schizophrenia: the findings of the Research on Asian Psychotropic Prescription Pattern (REAP) survey (2001-2009)[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2011,49(6):382-387.
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