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Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis
Yao, Yao1,2; Ma, Cai-hong3; Tang, Hui-lin1; Hu, Yong-fang1
关键词IVF FSHR Single nucleotide polymorphism Meta-analysis
刊名MOLECULAR GENETICS AND METABOLISM
2011-08-01
DOI10.1016/j.ymgme.2011.04.005
103期:4页:388-393
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]GENE POLYMORPHISMS ; HYPERSTIMULATION ; IVF ; PHARMACOGENETICS ; INFERTILITY ; GENOTYPE
英文摘要

Background: A common follicle-stimulating hormone (FSH) receptor (or FSHR) polymorphism Ser680Asn (rs6166) was found to be associated with altered ovarian response in women undergoing in-vitro fertilization. To further investigate such an association, a meta-analysis was conducted.

Methods: A PubMed literature search was conducted to identify all cohort studies investigating such a relationship. The following parameters-basal FSH levels, total FSH doses, oocytes retrieved, and pregnancy rates-were used to evaluate the ovarian function, its response to exogenous FSH and in-vitro fertilization and intracytoplasmic sperm injection outcome.

Results: A total of 1421 cases were collected from eight studies. Of them, a significantly lower basal FSH level was observed in patients harboring Asn/Asn (NN) genotype than those carrying the Ser/Ser (SS) genotype both in Asian (WMD: -2.57 mIU/ml, 95% CI: -2.96 to -2.19, P<0.0001) and Caucasian retrospective groups (WMD: -1.86 mIU/ml, 95%CI: -2.07 to -1.66, P<0.0001) with no heterogeneity. Moreover, carriers of the SS tended to require greater FSH doses than NN (WMD: -268.82 IU, 95% CI: -561.28 to 23.63, P = 0.07). Other parameters, such as oocytes retrieved and pregnancy rate, were not significantly different between the groups.

Conclusion: Carriers of the SS variant have slightly higher basal FSH levels, tending to require higher doses of exogenous FSH for stimulation. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000294096400013
项目编号81072705
资助机构National Nature Science Foundation of China
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67528
专题北京大学第三临床医学院
北京大学第三临床医学院_妇产科
北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Hosp 3, Therapeut Drug Monitoring & Clin Toxicol Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yao, Yao,Ma, Cai-hong,Tang, Hui-lin,et al. Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis[J]. MOLECULAR GENETICS AND METABOLISM,2011,103(4):388-393.
APA Yao, Yao,Ma, Cai-hong,Tang, Hui-lin,&Hu, Yong-fang.(2011).Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis.MOLECULAR GENETICS AND METABOLISM,103(4),388-393.
MLA Yao, Yao,et al."Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis".MOLECULAR GENETICS AND METABOLISM 103.4(2011):388-393.
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