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学科主题: 临床医学
题名:
Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis
作者: Yao, Yao1,2; Ma, Cai-hong3; Tang, Hui-lin1; Hu, Yong-fang1
关键词: IVF ; FSHR ; Single nucleotide polymorphism ; Meta-analysis
刊名: MOLECULAR GENETICS AND METABOLISM
发表日期: 2011-08-01
DOI: 10.1016/j.ymgme.2011.04.005
卷: 103, 期:4, 页:388-393
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]: GENE POLYMORPHISMS ; HYPERSTIMULATION ; IVF ; PHARMACOGENETICS ; INFERTILITY ; GENOTYPE
英文摘要:

Background: A common follicle-stimulating hormone (FSH) receptor (or FSHR) polymorphism Ser680Asn (rs6166) was found to be associated with altered ovarian response in women undergoing in-vitro fertilization. To further investigate such an association, a meta-analysis was conducted.

Methods: A PubMed literature search was conducted to identify all cohort studies investigating such a relationship. The following parameters-basal FSH levels, total FSH doses, oocytes retrieved, and pregnancy rates-were used to evaluate the ovarian function, its response to exogenous FSH and in-vitro fertilization and intracytoplasmic sperm injection outcome.

Results: A total of 1421 cases were collected from eight studies. Of them, a significantly lower basal FSH level was observed in patients harboring Asn/Asn (NN) genotype than those carrying the Ser/Ser (SS) genotype both in Asian (WMD: -2.57 mIU/ml, 95% CI: -2.96 to -2.19, P<0.0001) and Caucasian retrospective groups (WMD: -1.86 mIU/ml, 95%CI: -2.07 to -1.66, P<0.0001) with no heterogeneity. Moreover, carriers of the SS tended to require greater FSH doses than NN (WMD: -268.82 IU, 95% CI: -561.28 to 23.63, P = 0.07). Other parameters, such as oocytes retrieved and pregnancy rate, were not significantly different between the groups.

Conclusion: Carriers of the SS variant have slightly higher basal FSH levels, tending to require higher doses of exogenous FSH for stimulation. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81072705
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000294096400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67528
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Therapeut Drug Monitoring & Clin Toxicol Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China

Recommended Citation:
Yao, Yao,Ma, Cai-hong,Tang, Hui-lin,et al. Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: A meta-analysis[J]. MOLECULAR GENETICS AND METABOLISM,2011,103(4):388-393.
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