IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Synthesis of gamma-aminobutyric acid analogs based on carbohydrate scaffolds
Zhong, Ming; Meng, Xiang-Bao; Li, Zhong-Jun
关键词GABA analogs Glycal Vilsmeier-Haack reaction Sugar amino acids
刊名CARBOHYDRATE RESEARCH
2010-06-16
DOI10.1016/j.carres.2010.03.033
345期:9页:1099-1106
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SUGAR AMINO-ACIDS ; AMINOTRANSFERASE ; CONVERSION ; MIMETICS ; LACTAMS ; GLYCALS ; TARGETS ; DESIGN
英文摘要

gamma-Aminobutyric acid analogs based on sugar scaffolds were prepared in six to nine steps starting from D-glucal and D-galactal. The key step in the synthesis is the Vilsmeier-Haack reaction that affords the corresponding 2-C-formyl glycal on treatment with DMF and POCl3. Oxidation of the aldehyde and reduction of the 4-azido group provided the corresponding GABA analog. Acylamide and tetrazole analogs were also prepared as the bioisosteres of the carboxylic acid. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000279373200005
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67533
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Natl Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhong, Ming,Meng, Xiang-Bao,Li, Zhong-Jun. Synthesis of gamma-aminobutyric acid analogs based on carbohydrate scaffolds[J]. CARBOHYDRATE RESEARCH,2010,345(9):1099-1106.
APA Zhong, Ming,Meng, Xiang-Bao,&Li, Zhong-Jun.(2010).Synthesis of gamma-aminobutyric acid analogs based on carbohydrate scaffolds.CARBOHYDRATE RESEARCH,345(9),1099-1106.
MLA Zhong, Ming,et al."Synthesis of gamma-aminobutyric acid analogs based on carbohydrate scaffolds".CARBOHYDRATE RESEARCH 345.9(2010):1099-1106.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhong, Ming]的文章
[Meng, Xiang-Bao]的文章
[Li, Zhong-Jun]的文章
百度学术
百度学术中相似的文章
[Zhong, Ming]的文章
[Meng, Xiang-Bao]的文章
[Li, Zhong-Jun]的文章
必应学术
必应学术中相似的文章
[Zhong, Ming]的文章
[Meng, Xiang-Bao]的文章
[Li, Zhong-Jun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。