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学科主题: 基础医学
题名:
CMTMS-v1 induces apoptosis in cervical carcinoma cells
作者: Shao, Luning; Guo, Xiaohuan; Plate, Markus; Li, Ting; Wang, Yu; Ma, Dalong; Han, Wenling
关键词: CMTM5 ; Cervical carcinoma ; Apoptosis ; Tumorigenesis
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-02-20
DOI: 10.1016/j.bbrc.2008.12.126
卷: 379, 期:4, 页:866-871
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CHEMOKINE-LIKE FACTOR-1 ; FACTOR SUPERFAMILY ; MOLECULAR-CLONING ; CYTOCHROME-C ; PATHWAY ; TESTIS ; DEATH ; FORM
英文摘要:

CMTM5 (CKLF-like MARVEL transmembrane domain-containing member 5) exhibits tumor inhibition activity with frequent epigenetic inactivation in various tumor cell lines including cervical carcinoma (CC) cells. In this paper, we examined the function of CMTM5-v1 (the primary RNA splicing form) in both HeLa and SiHa cells. Overexpression of CMTM5-v1 in both cells can induce apoptosis, but the effects are more obvious in SiHa than that in HeLa. In SiHa cells, restoration of CMTM5-v1 caused disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase3 and cleavage of PARP. General caspase inhibitor almost prevented apoptosis of SiHa cells, suggesting that CMTM5-v1 induces apoptosis mainly through caspase-dependent pathway. These findings verify that CMTM5-v1 inhibits the growth of CC cell lines via inducing apoptosis. (C) 2008 Elsevier Inc. All rights reserved

语种: 英语
所属项目编号: 30571691 ; 2006AA02A305 ; NCET-07-0013
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China (863 Program) ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000263336700013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67535
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: Peking Univ, Ctr Human Dis Genom, Dept Immunol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Shao, Luning,Guo, Xiaohuan,Plate, Markus,et al. CMTMS-v1 induces apoptosis in cervical carcinoma cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(4):866-871.
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