学科主题基础医学
CMTMS-v1 induces apoptosis in cervical carcinoma cells
Shao, Luning; Guo, Xiaohuan; Plate, Markus; Li, Ting; Wang, Yu; Ma, Dalong; Han, Wenling
关键词CMTM5 Cervical carcinoma Apoptosis Tumorigenesis
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-02-20
DOI10.1016/j.bbrc.2008.12.126
379期:4页:866-871
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CHEMOKINE-LIKE FACTOR-1 ; FACTOR SUPERFAMILY ; MOLECULAR-CLONING ; CYTOCHROME-C ; PATHWAY ; TESTIS ; DEATH ; FORM
英文摘要

CMTM5 (CKLF-like MARVEL transmembrane domain-containing member 5) exhibits tumor inhibition activity with frequent epigenetic inactivation in various tumor cell lines including cervical carcinoma (CC) cells. In this paper, we examined the function of CMTM5-v1 (the primary RNA splicing form) in both HeLa and SiHa cells. Overexpression of CMTM5-v1 in both cells can induce apoptosis, but the effects are more obvious in SiHa than that in HeLa. In SiHa cells, restoration of CMTM5-v1 caused disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase3 and cleavage of PARP. General caspase inhibitor almost prevented apoptosis of SiHa cells, suggesting that CMTM5-v1 induces apoptosis mainly through caspase-dependent pathway. These findings verify that CMTM5-v1 inhibits the growth of CC cell lines via inducing apoptosis. (C) 2008 Elsevier Inc. All rights reserved

语种英语
WOS记录号WOS:000263336700013
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67535
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
作者单位Peking Univ, Ctr Human Dis Genom, Dept Immunol, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Shao, Luning,Guo, Xiaohuan,Plate, Markus,et al. CMTMS-v1 induces apoptosis in cervical carcinoma cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,379(4):866-871.
APA Shao, Luning.,Guo, Xiaohuan.,Plate, Markus.,Li, Ting.,Wang, Yu.,...&Han, Wenling.(2009).CMTMS-v1 induces apoptosis in cervical carcinoma cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,379(4),866-871.
MLA Shao, Luning,et al."CMTMS-v1 induces apoptosis in cervical carcinoma cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379.4(2009):866-871.
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