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学科主题: 临床医学
题名:
Endothelial Nitric Oxide Synthase 894G -> T But Not-786T -> C Gene Polymorphism Is Associated With Organ Dysfunction and Increased Mortality in Patients With Severe Sepsis
作者: Ma, Penglin1; Zhu, Ying1; Qiu, Haibo2; Liu, Jingtao1; Wang, Yu1; Zeng, Lin3
关键词: eNOS ; Gene polymorphism ; Severe sepsis ; Organ dysfunction
刊名: JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
发表日期: 2011-10-01
DOI: 10.1097/TA.0b013e31820277f0
卷: 71, 期:4, 页:872-877
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Surgery
研究领域[WOS]: General & Internal Medicine ; Surgery
关键词[WOS]: CORONARY-ARTERY-DISEASE ; IN-VITRO ; G894T ; LIPOPOLYSACCHARIDE ; HYPOTENSION ; EXPRESSION ; RESISTANCE ; FAILURE ; SHOCK ; MICE
英文摘要:

Background: Endothelial nitric oxide synthase (eNOS) -786T -> C and 894G -> T polymorphisms have been associated with eNOS dysfunction, which might further compromise microcirculatory blood flow during sepsis and increase the risk of organ injury. The purpose of this study is to investigate the association of those two eNOS gene polymorphisms with the severity of organ dysfunction and outcome in patients with severe sepsis.

Methods: A cohort of patients with severe sepsis was studied and genotyped for eNOS -786T -> C and 894G -> T polymorphisms. Acute Physical and Chronic Health Evaluation score, the Sequential Organ Failure Assessment score, with or without shock, and the outcomes were compared in patients with different genotypes.

Results: One hundred seventeen patients fulfilled with inclusion criteria were enrolled from nine intensive care units of academic hospital in Beijing. In comparison with the GG genotype, patients with the GT genotype (894G -> T) had a trend toward an increase in the frequency of shock (87% vs. 68.1%, p = 0.071) and significantly fewer days to shock onset (p < 0.05). Those patients also had significantly higher Acute Physical and Chronic Health Evaluation II scores (p < 0.05), Sequential Organ Failure Assessment scores (p < 0.001), and mortality at both 7 days and 28 days (p < 0.001). Multivariate analyses identified the GT genotype (894G -> T) as an independent risk factor for outcome in patients with severe sepsis. However, we found that the eNOS -786T -> C polymorphism was not associated with severity of disease or mortality of patients with sepsis.

Conclusions: Carriage of the GT genotype at 894 of eNOS gene was associated with the occurrence of shock and impaired organ function.

语种: 英语
WOS记录号: WOS:000295925700024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67544
Appears in Collections:北京大学第三临床医学院_临床流行病学研究中心_期刊论文

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作者单位: 1.309th Hosp Chinese Peoples Liberat Army, ICU, Beijing 100091, Peoples R China
2.Southeast Univ, Nanjing Zhongda Hosp, Intens Care Unit, Nanjing, Peoples R China
3.Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Penglin,Zhu, Ying,Qiu, Haibo,et al. Endothelial Nitric Oxide Synthase 894G -&gt; T But Not-786T -&gt; C Gene Polymorphism Is Associated With Organ Dysfunction and Increased Mortality in Patients With Severe Sepsis[J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE,2011,71(4):872-877.
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