|Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012|
|Wang, Yu-Xi1,2; Xiang, Yu-Tao3; Su, Yun-Ai1,2; Li, Qian1,2; Shu, Liang1,2; Ng, Chee H.4; Ungvari, Gabor S.5,6; Chiu, Helen F. K.7; Nin, Yu-Ping8; Wang, Gao-Hua9; Bai, Pei-Shen10; Li, Tao11; Sun, Li-Zhong12; Shi, Jian-Guo13; Chen, Xian-Sheng14; Mei, Qi-Yi15; Li, Ke-Qing16; Yu, Xin1,2; Si, Tian-Mei1,2|
|关键词||Antipsychotic Medication Major Depression Prescription Patterns|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||DRUG PRESCRIPTION ; DISORDER ; AUGMENTATION ; ANTIDEPRESSANTS ; SCHIZOPHRENIA ; METAANALYSIS ; MANAGEMENT ; PATTERNS ; ASIA|
Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL).
Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection.
Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (chi(2) = 90.3, df = 2, P < 0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups.
Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients and relatives satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.
|资助机构||12th Five-year Plan of the National Key Technologies R and D Program of China|
|作者单位||1.Hebei Mental Hlth Ctr, Baoding 071051, Hebei, Peoples R China|
2.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
3.Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
4.Guangzhou Psychiat Hosp, Guangzhou 510370, Guangdong, Peoples R China
5.Neuropsychiat Hosp, Siping 136000, Jilin, Peoples R China
6.Shaanxi Mental Hlth Ctr, Xian 710061, Shaanxi, Peoples R China
7.Jiangxi Mental Hlth Ctr, Nanchang 330029, Jiangxi, Peoples R China
8.Suzhou Guangji Hosp, Suzhou 215008, Jiangsu, Peoples R China
9.Peking Univ, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China
10.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
11.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
12.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Hubei, Peoples R China
15.Shanxi Med Univ, Hosp 1, Dept Mental Hlth, Taiyuan 030001, Shanxi, Peoples R China
16.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China
|Wang, Yu-Xi,Xiang, Yu-Tao,Su, Yun-Ai,et al. Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012[J]. CHINESE MEDICAL JOURNAL,2015,128(14):1847-1852.|
|APA||Wang, Yu-Xi.,Xiang, Yu-Tao.,Su, Yun-Ai.,Li, Qian.,Shu, Liang.,...&Si, Tian-Mei.(2015).Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012.CHINESE MEDICAL JOURNAL,128(14),1847-1852.|
|MLA||Wang, Yu-Xi,et al."Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012".CHINESE MEDICAL JOURNAL 128.14(2015):1847-1852.|