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学科主题: 精神卫生
题名:
Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012
作者: Wang, Yu-Xi1,2; Xiang, Yu-Tao3; Su, Yun-Ai1,2; Li, Qian1,2; Shu, Liang1,2; Ng, Chee H.4; Ungvari, Gabor S.5,6; Chiu, Helen F. K.7; Nin, Yu-Ping8; Wang, Gao-Hua9; Bai, Pei-Shen10; Li, Tao11; Sun, Li-Zhong12; Shi, Jian-Guo13; Chen, Xian-Sheng14; Mei, Qi-Yi15; Li, Ke-Qing16; Yu, Xin1,2; Si, Tian-Mei1,2
关键词: Antipsychotic Medication ; Major Depression ; Prescription Patterns
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-07-20
DOI: 10.4103/0366-6999.160485
卷: 128, 期:14, 页:1847-1852
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: DRUG PRESCRIPTION ; DISORDER ; AUGMENTATION ; ANTIDEPRESSANTS ; SCHIZOPHRENIA ; METAANALYSIS ; MANAGEMENT ; PATTERNS ; ASIA
英文摘要:

Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL).

Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection.

Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (chi(2) = 90.3, df = 2, P < 0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups.

Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients and relatives satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.

语种: 英语
所属项目编号: 2011ZX09302-004
项目资助者: 12th Five-year Plan of the National Key Technologies R and D Program of China
WOS记录号: WOS:000358430300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67545
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Hebei Mental Hlth Ctr, Baoding 071051, Hebei, Peoples R China
2.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
3.Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
4.Guangzhou Psychiat Hosp, Guangzhou 510370, Guangdong, Peoples R China
5.Neuropsychiat Hosp, Siping 136000, Jilin, Peoples R China
6.Shaanxi Mental Hlth Ctr, Xian 710061, Shaanxi, Peoples R China
7.Jiangxi Mental Hlth Ctr, Nanchang 330029, Jiangxi, Peoples R China
8.Suzhou Guangji Hosp, Suzhou 215008, Jiangsu, Peoples R China
9.Peking Univ, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing 100191, Peoples R China
10.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
11.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
12.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Hubei, Peoples R China
15.Shanxi Med Univ, Hosp 1, Dept Mental Hlth, Taiyuan 030001, Shanxi, Peoples R China
16.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China

Recommended Citation:
Wang, Yu-Xi,Xiang, Yu-Tao,Su, Yun-Ai,et al. Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012[J]. CHINESE MEDICAL JOURNAL,2015,128(14):1847-1852.
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