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学科主题临床医学
An in situ-forming zwitterionic hydrogel as vitreous substitute
Chang, Jing1,3; Tao, Yong2; Wang, Bin2; Guo, Bao-hua1; Xu, Hong3; Jiang, Yan-rong2; Huang, Yanbin1
刊名JOURNAL OF MATERIALS CHEMISTRY B
2015
DOI10.1039/c4tb01775g
3期:6页:1097-1105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]MICHAEL ADDITION ; DESIGN ; BIOMATERIALS ; POLYMERS ; VITRO ; GELS
英文摘要

Zwitterionic polymers have shown ultra-low biofouling properties at surfaces and excellent biocompatibility as implant. In this study, an in situ-forming zwitterionic hydrogel was designed and evaluated, both in vitro and in vivo, as a long-term vitreous substitute. The zwitterionic polymer poly(MPDSA-co-AC) was designed as a copolymer of the sulfobetaine methacrylamide and acryloyl cystamine monomers, providing the zwitterionic components and the thiol functional groups, respectively. The in situ gelation was via the thiol-ene Michael addition reaction with alpha-PEG-MA as the crosslinker. The gelation time, rheological properties, swelling profiles, and the transparency of zwitterionic hydrogels were studied in detail. Two systems with different crosslinker concentrations were tested in a rabbit model, and the one with the thiol-ene ratio of 2 : 1 showed excellent biocompatibility in vivo, formed space-filling hydrogels and remained transparent in the vitreous cavity for the 2 month implantation period. Therefore, in situ-forming zwitterionic hydrogels represent a promising material system as a vitreous substitute and possibly for other soft tissue replacements.

语种英语
WOS记录号WOS:000349146700018
项目编号Z121100005212003
资助机构Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67554
专题北京大学第二临床医学院_眼科
作者单位1.Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat MOE, Beijing 100084, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100044, Peoples R China
3.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing 211816, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Chang, Jing,Tao, Yong,Wang, Bin,et al. An in situ-forming zwitterionic hydrogel as vitreous substitute[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(6):1097-1105.
APA Chang, Jing.,Tao, Yong.,Wang, Bin.,Guo, Bao-hua.,Xu, Hong.,...&Huang, Yanbin.(2015).An in situ-forming zwitterionic hydrogel as vitreous substitute.JOURNAL OF MATERIALS CHEMISTRY B,3(6),1097-1105.
MLA Chang, Jing,et al."An in situ-forming zwitterionic hydrogel as vitreous substitute".JOURNAL OF MATERIALS CHEMISTRY B 3.6(2015):1097-1105.
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