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学科主题: 临床医学
题名:
An in situ-forming zwitterionic hydrogel as vitreous substitute
作者: Chang, Jing1,3; Tao, Yong2; Wang, Bin2; Guo, Bao-hua1; Xu, Hong3; Jiang, Yan-rong2; Huang, Yanbin1
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2015
DOI: 10.1039/c4tb01775g
卷: 3, 期:6, 页:1097-1105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: MICHAEL ADDITION ; DESIGN ; BIOMATERIALS ; POLYMERS ; VITRO ; GELS
英文摘要:

Zwitterionic polymers have shown ultra-low biofouling properties at surfaces and excellent biocompatibility as implant. In this study, an in situ-forming zwitterionic hydrogel was designed and evaluated, both in vitro and in vivo, as a long-term vitreous substitute. The zwitterionic polymer poly(MPDSA-co-AC) was designed as a copolymer of the sulfobetaine methacrylamide and acryloyl cystamine monomers, providing the zwitterionic components and the thiol functional groups, respectively. The in situ gelation was via the thiol-ene Michael addition reaction with alpha-PEG-MA as the crosslinker. The gelation time, rheological properties, swelling profiles, and the transparency of zwitterionic hydrogels were studied in detail. Two systems with different crosslinker concentrations were tested in a rabbit model, and the one with the thiol-ene ratio of 2 : 1 showed excellent biocompatibility in vivo, formed space-filling hydrogels and remained transparent in the vitreous cavity for the 2 month implantation period. Therefore, in situ-forming zwitterionic hydrogels represent a promising material system as a vitreous substitute and possibly for other soft tissue replacements.

语种: 英语
所属项目编号: Z121100005212003
项目资助者: Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000349146700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67554
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat MOE, Beijing 100084, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100044, Peoples R China
3.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing 211816, Jiangsu, Peoples R China

Recommended Citation:
Chang, Jing,Tao, Yong,Wang, Bin,et al. An in situ-forming zwitterionic hydrogel as vitreous substitute[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(6):1097-1105.
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