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学科主题: 临床医学
题名:
Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol
作者: Geng, B; Chang, L; Pan, CS; Qi, YF; Zhao, J; Pang, YZ; Du, JB; Tang, CS
关键词: hydrogen sulfide ; cystathionine ; gamma-synthase ; cardiac ischemia ; isoproterenol
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2004-06-04
DOI: 10.1016/j.bbrc.2004.04.094
卷: 318, 期:3, 页:756-763
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NITRIC-OXIDE ; RAT ; HEART ; H2S ; CATECHOLAMINE ; HYPERTENSION ; BRAIN ; NEUROMODULATOR ; PATHOGENESIS ; HOMOCYSTEINE
英文摘要:

Previous work has shown that the endogenous cystathionine gamma-synthase (CSE)/hydrogen sulfide (H2S) pathway participates in the regulation of cardiac contraction. We hypothesized that the pathway might participate in the pathophysiological regulation of ischemic heart disease. Isoproterenol injection of rat hearts induced a myocardial ischemic injury model, with reduced myocardial and plasma H2S levels, decreased C-SE activity, and upregulated CSE gene expression. Exogenous administration of the H2S donor NaHS reduced the mortality rate: increased left-ventricular pressure development and left-ventricular-end systolic pressure; and decreased left-ventricular-end diastolic pressure (LVEDP) and subendocardial necrosis, capillary dilatation, leukocytic infiltration, fibroblast swelling, and fibroblastic hyperplasia. As well, production of lipid peroxidation, including myocardial malondialdehyde (MDA), and plasma MDA and Conjugated diene, was reduced. Oxidative stress injury is an important mechanism of isoproterenol-induced myocardial injury. In vitro experiments revealed that NaHS might antagonize myocyte MDA production by oxygen-free radicals and that NaHS directly scavenged hydrogen peroxide and superoxide anions. Our results suggest that the endogenous CSE/H2S pathway contributes to the pathogenesis of isoprotereriol-induccd myocardial injury. Administration of exogenous H2S effectively protects myocytes and contractile activity, at least by its direct scavenging of oxygen-free radicals and reducing the accumulation of lipid peroxidations. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000221674400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67555
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Dept Pediat, Beijing, Peoples R China
2.Peking Univ First Hosp, Inst Cardiovasc Res, Beijing, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Dept Physiol, Beijing, Peoples R China

Recommended Citation:
Geng, B,Chang, L,Pan, CS,et al. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,318(3):756-763.
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