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Myricetin Protects Against Cytokine-Induced Cell Death in RIN-m5f beta Cells
Ding, Ye; Zhang, Zhao-Feng; Dai, Xiao-Qian; Li, Yong
关键词cytokines mitochondrial death pathway myricetin nuclear factor kappa B RIN-m5f beta cells
刊名JOURNAL OF MEDICINAL FOOD
2012-08-01
DOI10.1089/jmf.2011.2033
15期:8页:733-740
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Food Science & Technology ; Nutrition & Dietetics
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Pharmacology & Pharmacy ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]INSULIN-PRODUCING CELLS ; NITRIC-OXIDE ; KAPPA-B ; PROINFLAMMATORY CYTOKINES ; SIGNAL-TRANSDUCTION ; APOPTOSIS ; INHIBITION ; PATHWAY ; ACTIVATION ; RATS
英文摘要

Cytokine-induced cell death is recognized as a major cause of progressive beta-cell loss. Tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and interferon gamma (IFN-gamma) in combination trigger a series of events that lead to beta-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytoprotective agent has gained much attention. The present study focused on the protective roles of myricetin against cytokine-induced cell death in insulin-secreting RIN-m5f beta cells. The results showed that myricetin (especially at concentrations of 10 mu M and 20 mu M) increased cell viability and decreased cell apoptosis induced by the cytokine mixture of TNF-alpha (10 ng/mL), IL-1 beta (5 ng/mL), and IFN-gamma (1000 IU/mL) for 3 days. Moreover, the cytokines increased the total and p65 subunit levels of nuclear factor kappa B, decreased inhibitor kappa B alpha levels, stimulated the accumulation of nitric oxide, increased cytochrome c release from mitochondria, and induced reactive oxygen species generation; myricetin (especially at the concentration of 20 mu M) abolished all of these parameters. These results suggest that myricetin might have therapeutic value for preventing beta-cell death.

语种英语
所属项目编号2006BAD27B01
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000307020300009
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67561
Collection北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ding, Ye,Zhang, Zhao-Feng,Dai, Xiao-Qian,et al. Myricetin Protects Against Cytokine-Induced Cell Death in RIN-m5f beta Cells[J]. JOURNAL OF MEDICINAL FOOD,2012,15(8):733-740.
APA Ding, Ye,Zhang, Zhao-Feng,Dai, Xiao-Qian,&Li, Yong.(2012).Myricetin Protects Against Cytokine-Induced Cell Death in RIN-m5f beta Cells.JOURNAL OF MEDICINAL FOOD,15(8),733-740.
MLA Ding, Ye,et al."Myricetin Protects Against Cytokine-Induced Cell Death in RIN-m5f beta Cells".JOURNAL OF MEDICINAL FOOD 15.8(2012):733-740.
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