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学科主题: 公共卫生
题名:
The anxiolytic effect of cinnabar involves changes of serotonin levels
作者: Wang, Qi; Yang, Xiaoda; Zhang, Baoxu; Yang, Xiuwei; Wang, Kui
关键词: cinnabar ; anxiolytic ; serotonin ; (mouse)
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2007-06-22
DOI: 10.1016/j.ejphar.2007.03.018
卷: 565, 期:1-3, 页:132-137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ELEVATED PLUS-MAZE ; MONOAMINE-OXIDASE ; 5-HT NEUROTRANSMISSION ; GENERALIZED ANXIETY ; BRAIN-STEM ; BEHAVIOR ; MOUSE ; RAT ; MEDICINES ; MERCURY
英文摘要:

The aim of this study was to explore the neurophannacological mechanism of cinnabar. The anxiolytic effect of cinnabar on anxiety-like behaviors in mice was investigated using the elevated plus maze test. The changes in the levels of monoamine neurotransmitters and their metabolites and the activity of monoamine oxidase (MAO) in the brain of mice were determined. The results indicate that cinnabar possessed anxiolytic effects after chronic administration (p.o.) at effective doses in association with the declined brain serotonin (5-HT) level. The cinnabar showed no effects on 5-HT metabolism pathway. The results suggested the potential importance of the brain serotonergic system. The 5-HT metabolism pathway may be not involved in the anxiolytic effects of cinnabar. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000247336500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67564
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,et al. The anxiolytic effect of cinnabar involves changes of serotonin levels[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,565(1-3):132-137.
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