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The anxiolytic effect of cinnabar involves changes of serotonin levels
Wang, Qi; Yang, Xiaoda; Zhang, Baoxu; Yang, Xiuwei; Wang, Kui
关键词cinnabar anxiolytic serotonin (mouse)
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2007-06-22
DOI10.1016/j.ejphar.2007.03.018
565期:1-3页:132-137
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ELEVATED PLUS-MAZE ; MONOAMINE-OXIDASE ; 5-HT NEUROTRANSMISSION ; GENERALIZED ANXIETY ; BRAIN-STEM ; BEHAVIOR ; MOUSE ; RAT ; MEDICINES ; MERCURY
英文摘要

The aim of this study was to explore the neurophannacological mechanism of cinnabar. The anxiolytic effect of cinnabar on anxiety-like behaviors in mice was investigated using the elevated plus maze test. The changes in the levels of monoamine neurotransmitters and their metabolites and the activity of monoamine oxidase (MAO) in the brain of mice were determined. The results indicate that cinnabar possessed anxiolytic effects after chronic administration (p.o.) at effective doses in association with the declined brain serotonin (5-HT) level. The cinnabar showed no effects on 5-HT metabolism pathway. The results suggested the potential importance of the brain serotonergic system. The 5-HT metabolism pathway may be not involved in the anxiolytic effects of cinnabar. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000247336500018
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67564
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,et al. The anxiolytic effect of cinnabar involves changes of serotonin levels[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,565(1-3):132-137.
APA Wang, Qi,Yang, Xiaoda,Zhang, Baoxu,Yang, Xiuwei,&Wang, Kui.(2007).The anxiolytic effect of cinnabar involves changes of serotonin levels.EUROPEAN JOURNAL OF PHARMACOLOGY,565(1-3),132-137.
MLA Wang, Qi,et al."The anxiolytic effect of cinnabar involves changes of serotonin levels".EUROPEAN JOURNAL OF PHARMACOLOGY 565.1-3(2007):132-137.
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