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学科主题临床医学
Glycoprotein non- metastatic melanoma protein B as a predictive prognostic factor in clear- cell renal cell carcinoma following radical nephrectomy
Qin, Caipeng1; Liu, Zhenhua1; Yuan, Yeqing1; Zhang, Xiaowei1; Li, Henan2; Zhang, Chunfang3; Xu, Tao1; Wang, Xiaofeng1
关键词clear-cell renal cell carcinoma metastasis glycoprotein non-metastatic melanoma protein B prognosis
刊名MOLECULAR MEDICINE REPORTS
2014-03-01
DOI10.3892/mmr.2014.1896
9期:3页:851-856
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]GENE-EXPRESSION ; CANCER METASTASIS ; OSTEOACTIVIN ; GPNMB ; BONE ; PATHWAY ; MARKER ; TARGET ; LINES ; P53
英文摘要

Current cancer therapies are largely reliant upon drugs and radiation that kill dividing cells or inhibit cell division in the primary tumor after radical surgery, whereas metastatic tumors should be more commonly the focus of targeted molecular therapies. Glycoprotein non-metastatic melanoma protein B (Gpnmb) is expressed in various types of cancer, and promotes the migration, invasion and metastasis of tumor cells. Thus, it was hypothesized that a unique clear-cell renal carcinoma (ccRCC) subclone expressing a high level of Gpnmb may metastasize more easily and thus be associated with poor prognosis. In the present study, the expression of Gpnmb was analyzed in primary and metastatic ccRCC samples, and the expression levels of Gpnmb were significantly higher in metastatic ccRCCs than in matched primary samples (P=0.036). Receiver operating characteristic (ROC) curve analysis was then performed to determine a cutoff score for Gpnmb expression in another 43 primary ccRCCs. For validation, the ROC-derived cutoff score was subjected to an analysis of the association between Gpnmb expression and patient outcome/clinical characteristics. Kaplan-Meier analysis demonstrated that elevated Gpnmb expression predicted a poorer overall survival (OS) in 43 cases of primary ccRCC. In addition, multivariate analyses revealed that Gpnmb expression served as an independent risk factor for ccRCC. Thus, the overexpression of Gpnmb identified patients at high risk and Gpnmb is a potential therapeutic molecular target for this type of tumor.

语种英语
WOS记录号WOS:000332699000012
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67568
Collection北京大学第二临床医学院_泌尿外科
作者单位1.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Sci Res, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Qin, Caipeng,Liu, Zhenhua,Yuan, Yeqing,et al. Glycoprotein non- metastatic melanoma protein B as a predictive prognostic factor in clear- cell renal cell carcinoma following radical nephrectomy[J]. MOLECULAR MEDICINE REPORTS,2014,9(3):851-856.
APA Qin, Caipeng.,Liu, Zhenhua.,Yuan, Yeqing.,Zhang, Xiaowei.,Li, Henan.,...&Wang, Xiaofeng.(2014).Glycoprotein non- metastatic melanoma protein B as a predictive prognostic factor in clear- cell renal cell carcinoma following radical nephrectomy.MOLECULAR MEDICINE REPORTS,9(3),851-856.
MLA Qin, Caipeng,et al."Glycoprotein non- metastatic melanoma protein B as a predictive prognostic factor in clear- cell renal cell carcinoma following radical nephrectomy".MOLECULAR MEDICINE REPORTS 9.3(2014):851-856.
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