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学科主题: 药学
题名:
Constituents of Vigna angularis and their in vitro anti-inflammatory activity
作者: Jiang, Yong1,2; Zeng, Ke-Wu1; David, Bruno2; Massiot, Georges3
关键词: Vigna angularis ; Leguminosae ; Furanylmethyl glycosides ; ent-Kaurane diterpene glycosides ; Triterpene saponins ; Anti-inflammatory activity
刊名: PHYTOCHEMISTRY
发表日期: 2014-11-01
DOI: 10.1016/j.phytochem.2014.08.011
卷: 107, 页:111-118
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: BLOOD-PRESSURE ELEVATION ; HOT-WATER EXTRACT ; CHEMICAL-CONSTITUENTS ; WILLD OHWI ; RHEUMATOID-ARTHRITIS ; SEEDS ; GLYCOSIDES ; SAPOGENOL ; SAPONIN ; OHASHI
英文摘要:

Nine non-phenolic compounds, including four furanylmethyl glycosides, angularides A-D, one ent-kaurane diterpene glycoside, angularin A, and four triterpenoid saponins, angulasaponins A-D, were isolated from seeds of Vigna angularis, together with eight known compounds. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analysis as well as chemical methods. Angularin A, angulasaponins A-C, and azukisaponins III and VI showed inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values ranging from 13 mu M to 24 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81222051 ; 2012ZX09301002-002-002 ; 2012ZX 09304-005
项目资助者: Fondation Franco-Chinoise pour la Science et ses Applications (FFCSA) ; China Scholarship Council (CSC) ; National Science Fund for Excellent Young Scholars of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000343840500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67575
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Inst Rech Pierre Fabre, Pole Actifs Vegetaux, F-31035 Toulouse 1, France
3.USR CNRS, Pierre Fabre ETaC 3388, Ctr Rech & Dev Pierre Fabre, F-31035 Toulouse 01, France

Recommended Citation:
Jiang, Yong,Zeng, Ke-Wu,David, Bruno,et al. Constituents of Vigna angularis and their in vitro anti-inflammatory activity[J]. PHYTOCHEMISTRY,2014,107:111-118.
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