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A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients
Zhang, Tong1; Jing, Xue2; Zhao, Xingquan1; Wang, Chunxue1; Liu, Zhaorui3; Zhou, Yong1; Wang, Yilong1; Wang, Yongjun1
关键词Post-stroke depression Lesion Location Infarct WHO-CIDI
刊名JOURNAL OF AFFECTIVE DISORDERS
2012
DOI10.1016/j.jad.2011.06.014
136期:1-2页:E83-E87
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]WHITE-MATTER HYPERINTENSITIES ; STROKE DATA-BANK ; FOLLOW-UP ; BIPOLAR DISORDER ; PATHOPHYSIOLOGY ; PERSONALITY ; PREVALENCE ; FREQUENCY ; SYMPTOMS
英文摘要

Background: Post-stroke depression (PSD) is a common consequence of stroke that negatively interferes with the rehabilitation outcome in patients. It remains unclear what relationship exists between the site and size of brain infarcts and the development of PSD and the risk factors for PSD. We conducted a MRI-based cohort study to examine the radiological correlations for PSD in Chinese patients with ischemic stroke.

Methods: Our study included 163 patients with acute ischemic stroke. The diagnosis of PSD was made with World Health Organization Composite International Diagnostic Interview (WHO-CIDI), which is based on Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) during a follow-up exam at 3-month post stroke. The demographic, clinical, and detailed radiological variables (e.g., lesion location, and degree of white matter lesions) were also examined.

Results: The univariate analyses suggested that the frequency of multiple acute infarcts, the total number and volume of acute infarcts were higher in the PSD group than those in the non-PSD group. In particular, PSD patients showed higher rates of infarcts in cortical-subcortical area of the frontal and temporal lobe as well as in internal capsule (including genu, anterior and posterior limb). The multivariate analysis suggested that independent radiological risk factors for PSD may include the presence of multiple acute infarcts, the infarct affecting either side of posterior limb of internal capsule, genu of internal capsule, and cortical-subcortical areas in the temporal lobe.

Conclusion: Our study on ischemic stroke patients suggested that certain neuroanatomical factors (i.e., lesions at posterior limb and genu of internal capsule and cortical-subcortical area of the temporal lobe, as well as the presence of multiple acute infarcts) may correlate with the PSD development. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000310897500010
项目编号D0905004000011 ; 2006BA101A11
资助机构Beijing Science and Technology Committee ; National 11th five-year Scientific and Technological Brainstorm Project ; Wyeth (China) Pharmaceutical Co. Ltd.
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67579
专题北京大学精神卫生研究所
北京大学第一临床医学院_门诊部
作者单位1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
3.Capital Univ Med Sci, Affiliated Beijing Tiantan Hosp, Beijing Neurosurg Inst, Dept Neuroradiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Tong,Jing, Xue,Zhao, Xingquan,et al. A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients[J]. JOURNAL OF AFFECTIVE DISORDERS,2012,136(1-2):E83-E87.
APA Zhang, Tong.,Jing, Xue.,Zhao, Xingquan.,Wang, Chunxue.,Liu, Zhaorui.,...&Wang, Yongjun.(2012).A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients.JOURNAL OF AFFECTIVE DISORDERS,136(1-2),E83-E87.
MLA Zhang, Tong,et al."A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients".JOURNAL OF AFFECTIVE DISORDERS 136.1-2(2012):E83-E87.
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