北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients
作者: Zhang, Tong1; Jing, Xue2; Zhao, Xingquan1; Wang, Chunxue1; Liu, Zhaorui3; Zhou, Yong1; Wang, Yilong1; Wang, Yongjun1
关键词: Post-stroke depression ; Lesion ; Location ; Infarct ; WHO-CIDI
刊名: JOURNAL OF AFFECTIVE DISORDERS
发表日期: 2012
DOI: 10.1016/j.jad.2011.06.014
卷: 136, 期:1-2, 页:E83-E87
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: WHITE-MATTER HYPERINTENSITIES ; STROKE DATA-BANK ; FOLLOW-UP ; BIPOLAR DISORDER ; PATHOPHYSIOLOGY ; PERSONALITY ; PREVALENCE ; FREQUENCY ; SYMPTOMS
英文摘要:

Background: Post-stroke depression (PSD) is a common consequence of stroke that negatively interferes with the rehabilitation outcome in patients. It remains unclear what relationship exists between the site and size of brain infarcts and the development of PSD and the risk factors for PSD. We conducted a MRI-based cohort study to examine the radiological correlations for PSD in Chinese patients with ischemic stroke.

Methods: Our study included 163 patients with acute ischemic stroke. The diagnosis of PSD was made with World Health Organization Composite International Diagnostic Interview (WHO-CIDI), which is based on Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) during a follow-up exam at 3-month post stroke. The demographic, clinical, and detailed radiological variables (e.g., lesion location, and degree of white matter lesions) were also examined.

Results: The univariate analyses suggested that the frequency of multiple acute infarcts, the total number and volume of acute infarcts were higher in the PSD group than those in the non-PSD group. In particular, PSD patients showed higher rates of infarcts in cortical-subcortical area of the frontal and temporal lobe as well as in internal capsule (including genu, anterior and posterior limb). The multivariate analysis suggested that independent radiological risk factors for PSD may include the presence of multiple acute infarcts, the infarct affecting either side of posterior limb of internal capsule, genu of internal capsule, and cortical-subcortical areas in the temporal lobe.

Conclusion: Our study on ischemic stroke patients suggested that certain neuroanatomical factors (i.e., lesions at posterior limb and genu of internal capsule and cortical-subcortical area of the temporal lobe, as well as the presence of multiple acute infarcts) may correlate with the PSD development. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: D0905004000011 ; 2006BA101A11
项目资助者: Beijing Science and Technology Committee ; National 11th five-year Scientific and Technological Brainstorm Project ; Wyeth (China) Pharmaceutical Co. Ltd.
WOS记录号: WOS:000310897500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67579
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
3.Capital Univ Med Sci, Affiliated Beijing Tiantan Hosp, Beijing Neurosurg Inst, Dept Neuroradiol, Beijing, Peoples R China

Recommended Citation:
Zhang, Tong,Jing, Xue,Zhao, Xingquan,et al. A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients[J]. JOURNAL OF AFFECTIVE DISORDERS,2012,136(1-2):E83-E87.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Tong]'s Articles
[Jing, Xue]'s Articles
[Zhao, Xingquan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Tong]‘s Articles
[Jing, Xue]‘s Articles
[Zhao, Xingquan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace