IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability
Ma, XC; Sha, YL; Lin, KH; Nie, SQ
刊名PROTEIN AND PEPTIDE LETTERS
2002-04-01
9期:2页:173-178
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ALZHEIMERS-DISEASE
英文摘要

The time course of A beta fibril formation was characterized using a variety of assays. The effect of A beta on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS/DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated A beta may decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose-dependent manner. These effects may have some relation with A beta neurotoxicity.

语种英语
WOS记录号WOS:000175150300011
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67581
专题北京大学基础医学院_生物物理学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ma, XC,Sha, YL,Lin, KH,et al. The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability[J]. PROTEIN AND PEPTIDE LETTERS,2002,9(2):173-178.
APA Ma, XC,Sha, YL,Lin, KH,&Nie, SQ.(2002).The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability.PROTEIN AND PEPTIDE LETTERS,9(2),173-178.
MLA Ma, XC,et al."The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability".PROTEIN AND PEPTIDE LETTERS 9.2(2002):173-178.
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