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学科主题: 基础医学
题名:
The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability
作者: Ma, XC; Sha, YL; Lin, KH; Nie, SQ
刊名: PROTEIN AND PEPTIDE LETTERS
发表日期: 2002-04-01
卷: 9, 期:2, 页:173-178
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: ALZHEIMERS-DISEASE
英文摘要:

The time course of A beta fibril formation was characterized using a variety of assays. The effect of A beta on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS/DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated A beta may decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose-dependent manner. These effects may have some relation with A beta neurotoxicity.

语种: 英语
WOS记录号: WOS:000175150300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67581
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100083, Peoples R China

Recommended Citation:
Ma, XC,Sha, YL,Lin, KH,et al. The effect of fibrillar Alpha beta(1-40) on membrane fluidity and permeability[J]. PROTEIN AND PEPTIDE LETTERS,2002,9(2):173-178.
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