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In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel
Chen, DB; Yang, TZ; Lu, WL; Zhang, Q
关键词stearic acid solid lipid nanoparticle Brij78 poloxamer F-68 paclitaxel long-circulating
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2001-11-01
49期:11页:1444-1447
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
英文摘要

Paclitaxel (Taxol), a diterpenoid isolated from Taxus brevifolia, is effective against several murine tumors, and is one of the most exciting anticancer molecules currently available. Due to its low solubility in water, it is clinically administered with polyethoxylated castor oil (Cremophor EL), which causes serious side effects. Inclusion of paclitaxel in solid lipid nanoparticles (SLNs) has proved to be a good approach to eliminate the need for Cremophor EL and improve the drug′s antitumor efficacy. This paper describes the development of two types of long-circulating SLNs as colloidal carriers for paclitaxel. SLNs are constituted mainly of bioacceptable and biodegradable lipids. In vitro release kinetics showed that the release was very slow, the release of paclitaxel from F-68-SLN is linear, and the release of paclitaxel from Brij78-SLN followed the Weibull equation. Pharmacokinetics was evaluated in KM mice after injection of paclitaxel formulated in Cremophor EL or in Brij78-SLN and F-68-SLN. Encapsulation of paclitaxel in both SLNs produced marked differences compared with the free drug pharmacokinetics. F-68-SLN and Brij78-SLN are long-circulating (t(1/2)beta, 10.06 and 4.88 h, respectively) compared with paclitaxel injection (t(1/2)beta, 1.36 h).

语种英语
WOS记录号WOS:000171980200010
引用统计
被引频次:140[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67583
专题北京大学药学院_药剂学系
作者单位Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, DB,Yang, TZ,Lu, WL,et al. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2001,49(11):1444-1447.
APA Chen, DB,Yang, TZ,Lu, WL,&Zhang, Q.(2001).In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel.CHEMICAL & PHARMACEUTICAL BULLETIN,49(11),1444-1447.
MLA Chen, DB,et al."In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel".CHEMICAL & PHARMACEUTICAL BULLETIN 49.11(2001):1444-1447.
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