北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel
作者: Chen, DB; Yang, TZ; Lu, WL; Zhang, Q
关键词: stearic acid ; solid lipid nanoparticle ; Brij78 ; poloxamer F-68 ; paclitaxel ; long-circulating
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2001-11-01
卷: 49, 期:11, 页:1444-1447
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
英文摘要:

Paclitaxel (Taxol), a diterpenoid isolated from Taxus brevifolia, is effective against several murine tumors, and is one of the most exciting anticancer molecules currently available. Due to its low solubility in water, it is clinically administered with polyethoxylated castor oil (Cremophor EL), which causes serious side effects. Inclusion of paclitaxel in solid lipid nanoparticles (SLNs) has proved to be a good approach to eliminate the need for Cremophor EL and improve the drug′s antitumor efficacy. This paper describes the development of two types of long-circulating SLNs as colloidal carriers for paclitaxel. SLNs are constituted mainly of bioacceptable and biodegradable lipids. In vitro release kinetics showed that the release was very slow, the release of paclitaxel from F-68-SLN is linear, and the release of paclitaxel from Brij78-SLN followed the Weibull equation. Pharmacokinetics was evaluated in KM mice after injection of paclitaxel formulated in Cremophor EL or in Brij78-SLN and F-68-SLN. Encapsulation of paclitaxel in both SLNs produced marked differences compared with the free drug pharmacokinetics. F-68-SLN and Brij78-SLN are long-circulating (t(1/2)beta, 10.06 and 4.88 h, respectively) compared with paclitaxel injection (t(1/2)beta, 1.36 h).

语种: 英语
WOS记录号: WOS:000171980200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67583
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Chen, DB,Yang, TZ,Lu, WL,et al. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2001,49(11):1444-1447.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, DB]'s Articles
[Yang, TZ]'s Articles
[Lu, WL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, DB]‘s Articles
[Yang, TZ]‘s Articles
[Lu, WL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace