北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科  > 期刊论文
学科主题: 临床医学
题名:
Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3
作者: Shen, Zhanlong1,2,3; Ye, Yingjiang1; Kauttu, Tuuli2,3; Seppanen, Hanna2,3; Vainionpaa, Sanna2,3; Wang, Shan1; Mustonen, Harri2,3; Puolakkainen, Pauli2,3
关键词: kindlin-2 ; invasion ; metastasis ; integrin ; gastric cancer
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2013-08-01
DOI: 10.1002/jso.23353
卷: 108, 期:2, 页:106-112
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: MATRIX ADHESION ; METASTASIS ; GENE ; EXPRESSION ; MUTATIONS ; CARCINOMA ; COMPONENT
英文摘要:

Background We have found that the expression of the novel focal adhesion protein kindlin-2 had a significant positive correlation with poor survival in gastric cancer. However, the mechanism by which kindlin-2 acts in gastric cancer warrants further evaluation.

Methods Kindlin-2 mRNA expression in gastric cancer cell lines was measured by realtime RT-PCR under normal and hypoxic conditions. Cell proliferation, apoptosis, cell cycle, tumor adhesion, cell invasion ability, and phosphorylation of integrin 1 and 3 proteins were measured to assess the influence of kindlin-2 on the malignant behavior of gastric cancer cells.

Results Kindlin-2 mRNA expression was highest in the distant metastasis gastric cancer cell line Hs-746T. Cell proliferation, adhesion with endothelium and collagen IV, invasion rate, and angiogenesis genes expression, as well as phosphorylation of integrin 1 and 3 in Hs-746T, were decreased significantly after kindlin-2 downregulation, but there was no change in apoptosis and cell cycle.

Conclusions Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin 1 and 3. J. Surg. Oncol. 2013; 108:106-112. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: RDB 2012-18 ; 81072018
项目资助者: Sigrid Juselius Foundation ; Helsinki University Central Hospital Research Funds ; Peking University People&prime ; s Hospital Funds ; National Science Foundation of China
WOS记录号: WOS:000321778100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67588
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Helsinki, FIN-00290 Helsinki, Finland
2.Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China
3.Univ Helsinki, Cent Hosp, Dept Surg, FIN-00290 Helsinki, Finland

Recommended Citation:
Shen, Zhanlong,Ye, Yingjiang,Kauttu, Tuuli,et al. Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3[J]. JOURNAL OF SURGICAL ONCOLOGY,2013,108(2):106-112.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shen, Zhanlong]'s Articles
[Ye, Yingjiang]'s Articles
[Kauttu, Tuuli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shen, Zhanlong]‘s Articles
[Ye, Yingjiang]‘s Articles
[Kauttu, Tuuli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace