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Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3
Shen, Zhanlong1,2,3; Ye, Yingjiang1; Kauttu, Tuuli2,3; Seppanen, Hanna2,3; Vainionpaa, Sanna2,3; Wang, Shan1; Mustonen, Harri2,3; Puolakkainen, Pauli2,3
关键词kindlin-2 invasion metastasis integrin gastric cancer
刊名JOURNAL OF SURGICAL ONCOLOGY
2013-08-01
DOI10.1002/jso.23353
108期:2页:106-112
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]MATRIX ADHESION ; METASTASIS ; GENE ; EXPRESSION ; MUTATIONS ; CARCINOMA ; COMPONENT
英文摘要

Background We have found that the expression of the novel focal adhesion protein kindlin-2 had a significant positive correlation with poor survival in gastric cancer. However, the mechanism by which kindlin-2 acts in gastric cancer warrants further evaluation.

Methods Kindlin-2 mRNA expression in gastric cancer cell lines was measured by realtime RT-PCR under normal and hypoxic conditions. Cell proliferation, apoptosis, cell cycle, tumor adhesion, cell invasion ability, and phosphorylation of integrin 1 and 3 proteins were measured to assess the influence of kindlin-2 on the malignant behavior of gastric cancer cells.

Results Kindlin-2 mRNA expression was highest in the distant metastasis gastric cancer cell line Hs-746T. Cell proliferation, adhesion with endothelium and collagen IV, invasion rate, and angiogenesis genes expression, as well as phosphorylation of integrin 1 and 3 in Hs-746T, were decreased significantly after kindlin-2 downregulation, but there was no change in apoptosis and cell cycle.

Conclusions Kindlin-2 might promote the invasion of gastric cancer cells through enhancing proliferation and adhesion by the phosphorylation of integrin 1 and 3. J. Surg. Oncol. 2013; 108:106-112. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000321778100005
项目编号RDB 2012-18 ; 81072018
资助机构Sigrid Juselius Foundation ; Helsinki University Central Hospital Research Funds ; Peking University People&prime ; s Hospital Funds ; National Science Foundation of China
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67588
专题北京大学第二临床医学院_胃肠外科
作者单位1.Univ Helsinki, FIN-00290 Helsinki, Finland
2.Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China
3.Univ Helsinki, Cent Hosp, Dept Surg, FIN-00290 Helsinki, Finland
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Shen, Zhanlong,Ye, Yingjiang,Kauttu, Tuuli,et al. Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3[J]. JOURNAL OF SURGICAL ONCOLOGY,2013,108(2):106-112.
APA Shen, Zhanlong.,Ye, Yingjiang.,Kauttu, Tuuli.,Seppanen, Hanna.,Vainionpaa, Sanna.,...&Puolakkainen, Pauli.(2013).Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3.JOURNAL OF SURGICAL ONCOLOGY,108(2),106-112.
MLA Shen, Zhanlong,et al."Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin 1 and 3".JOURNAL OF SURGICAL ONCOLOGY 108.2(2013):106-112.
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