学科主题临床医学
Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China
He Quan-ying2; Feng Jing1; Zhang Xi-long3; Liang Zong-an4; Huang Shao-guang5; Kang Jian6; Wang Guang-fa7; Zhang Li-qiang8; Ma Li-jun9; Wang Bei10; Lin Qi-chang11; Zhang Jing-nong12; Liu Hui-guo13; Luo Yuan-ming14; Liu Jian-hong15; Wang Shi16; Xiao Gao-hui17; Lu Gan18; Zhang Jin19; Feng Xue-wei20; Chen Bao-yuan1; Chinese Med Assoc
关键词obstructive sleep apnea hypertension epidemiology blood pressure polysomnography
刊名CHINESE MEDICAL JOURNAL
2010-01-05
DOI10.3760/cma.j.issn.0366-6999.2010.01.003
123期:1页:18-22
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]POSITIVE AIRWAY PRESSURE ; INTERMITTENT HYPOXIA ; HONG-KONG ; PREVALENCE ; HYPERTENSION ; ASSOCIATION ; MEN ; COMMUNITY ; WOMEN ; RESISTANT
英文摘要

Background Epidemiologic studies have shown an independent and definite association between obstructive sleep apnea (OSA) and hypertension. This study aimed to define the association between daytime blood pressure and severity of OSA in Chinese population in mainland of China.

Methods Twenty university hospital sleep centers in mainland of China were invited by the Chinese Medical Association (CMA) to participate in this epidemiologic study and 2297 consecutive patients (aged 18-85 years; 1981 males and 316 females) referred to these twenty sleep centers for evaluation of OSA between January 2004 and April 2006 were prospectively enrolled. Nocturnal polysomnography was performed in each patient, and disease severity was assessed based on the apnea-hypopnea index (AHI). These patients were classfied into four groups: non-apneic control (control, n=257) with AHI <= 55 episodes/hour; mild sleep apnea (mild, n=402) with AHI >5 and 515 episodes/hour; moderate sleep apnea (moderate, n=460) with AHI >15 and <= 30 episodes/hour and severe sleep apnea (severe, n=1178) with AHI >30 episodes/hour. Daytime blood pressure measurements were performed under standardized conditions in each patient at 10 a.m. in office on the day of referring to sleep centers for getting average value. All the patients were requested to quit medications related to blood pressure for three days before the day of assessing.

Results Both daytime systolic blood pressure and diastolic blood pressure values were significantly related to AHI positively (r = 0.201 and 0.276, respectively; both P values <0.001) and to nadir nocturnal oxygen saturation negatively (r = -0.215 and -0.277, respectively; both P values <0.001) which were the parameters of OSA severity. In two special designed mean plots, means of daytime systolic and diastolic blood pressure increased gradually with increasing AHI. Beyond AHI of 61-65, this increasing trend reached a plateau.

Conclusions The results showed that OSA severity was associated with daytime blood pressure until AHI of 61-65, providing evidence for early OSA management, especially in OSA patients with concomitant hypertension. Chin Med J 2010;123(1):18-22

语种英语
WOS记录号WOS:000273899000004
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67590
专题北京大学第一临床医学院_呼吸和危重症医学科
北京大学第三临床医学院_呼吸科
作者单位1.Beijing Gongan Hosp, Dept Resp Dis, Beijing 100006, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Dept Resp Dis, Tianjin 300052, Peoples R China
3.Beijing Univ Peoples Hosp, Dept Resp Dis, Beijing 100044, Peoples R China
4.Nanjing Med Univ, Dept Resp Dis, Affiliated Hosp 1, Nanjing 210029, Peoples R China
5.Sichuan Univ, Dept Resp Dis, Huaxi Hosp, Chengdu 610041, Sichuan, Peoples R China
6.Shanghai Jiao Tong Univ, Dept Resp Dis, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China
7.China Med Univ, Dept Resp Dis, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China
8.Peking Univ, Dept Resp Dis, Hosp 1, Beijing 100034, Peoples R China
9.Peking Univ, Dept Resp Dis, Hosp 3, Beijing 100083, Peoples R China
10.Henan Prov Peoples Hosp, Dept Resp Dis, Zhengzhou 450003, Henan, Peoples R China
11.Shanxi Med Univ, Dept Resp Dis, Affiliated Hosp 2, Taiyuan 030001, Shanxi, Peoples R China
12.Fujian Med Univ, Dept Resp Dis, Affiliated Hosp 1, Fuzhou 350005, Fujian, Peoples R China
13.Huazhong Univ Sci & Technol, Dept Resp Dis, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China
14.Huazhong Univ Sci & Technol, Dept Resp Dis, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
15.Guangzhou Med Coll, Guangzhou Inst Resp Dis, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
16.Guangxi Zhuang Autonomous Reg Peoples Hosp, Dept Resp Dis, Nanning 530021, Guangxi, Peoples R China
17.Shenyang Med Coll, Dept Resp Dis, Cent Hosp, Shenyang 110024, Liaoning, Peoples R China
18.Jiangsu Senil Hosp, Dept Resp Dis, Nanjing 210024, Jiangsu, Peoples R China
19.Ningxia Med Coll, Dept Resp Dis, Affiliated Hosp, Yinchuan 750004, Ningxia, Peoples R China
20.China Med Univ, Dept Resp Dis, Affiliated Hosp 2, Shenyang 110004, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
He Quan-ying,Feng Jing,Zhang Xi-long,et al. Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China[J]. CHINESE MEDICAL JOURNAL,2010,123(1):18-22.
APA He Quan-ying.,Feng Jing.,Zhang Xi-long.,Liang Zong-an.,Huang Shao-guang.,...&Chinese Med Assoc.(2010).Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China.CHINESE MEDICAL JOURNAL,123(1),18-22.
MLA He Quan-ying,et al."Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China".CHINESE MEDICAL JOURNAL 123.1(2010):18-22.
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