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学科主题临床医学
Current Understanding of HOG-MAPK Pathway in Aspergillus fumigatus
Ma, Dongmei1,2; Li, Ruoyu1,2
关键词Aspergillus fumigatus Mitogen-activated protein kinase HOG pathway Stress Morphology Virulence
刊名MYCOPATHOLOGIA
2013-02-01
DOI10.1007/s11046-012-9600-5
175期:1-2页:13-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
资助者National Foundation of Natural Sciences in China ; National Foundation of Natural Sciences in China
研究领域[WOS]Mycology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; PATHOGEN CANDIDA-ALBICANS ; 2-COMPONENT SIGNAL-TRANSDUCTION ; SKN7 RESPONSE REGULATOR ; YEAST SACCHAROMYCES-CEREVISIAE ; OXIDATIVE STRESS RESISTANCE ; PUTATIVE HISTIDINE KINASE ; CELL-WALL BIOSYNTHESIS ; RICE BLAST FUNGUS ; CRYPTOCOCCUS-NEOFORMANS
英文摘要

Aspergillus fumigatus is an important opportunistic fungal pathogen that causes lethal systemic invasive aspergillosis. It must be able to adapt to stress in the microenvironment during host invasion and systemic spread. The high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) signaling pathway is a key element that controls adaptation to environmental stress. It plays a critical role in the virulence of several fungal pathogens. In this review, we summarize the current knowledge about the functions of different components of the HOG-MAPK pathway in A. fumigatus through mutant analysis or inferences from the genome annotation, focusing on their roles in adaptation to stress, regulation of infection-related morphogenesis, and effect on virulence. We also briefly compare the functions of the HOG pathway in A. fumigatus with those in the model fungi Saccharomyces cerevisiae and Aspergillus nidulans as well as several other human and plant pathogens including Candida albicans, Cryptococcus neoformans, and Magnaporthe oryzae. The genes described in this review mainly include tcsB, fos1, skn7, sho1, pbs2, and sakA whose deletion mutants have already been established in A. fumigatus. Among them, fos1 has been considered a virulence factor in A. fumigatus, indicating that components of the HOG pathway may be suitable as targets for developing new fungicides. However, quite a few of the genes of this pathway, such as sskA (ssk1), sskB, steC, and downstream regulator genes, are not well characterized. System biology approaches may contribute to a more comprehensive understanding of HOG pathway functions with dynamic details.

语种英语
所属项目编号30930006
资助者National Foundation of Natural Sciences in China ; National Foundation of Natural Sciences in China
WOS记录号WOS:000313968100002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67592
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Ma, Dongmei,Li, Ruoyu. Current Understanding of HOG-MAPK Pathway in Aspergillus fumigatus[J]. MYCOPATHOLOGIA,2013,175(1-2):13-23.
APA Ma, Dongmei,&Li, Ruoyu.(2013).Current Understanding of HOG-MAPK Pathway in Aspergillus fumigatus.MYCOPATHOLOGIA,175(1-2),13-23.
MLA Ma, Dongmei,et al."Current Understanding of HOG-MAPK Pathway in Aspergillus fumigatus".MYCOPATHOLOGIA 175.1-2(2013):13-23.
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