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Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment
Li, Su-Xia1; Liu, Li-Jing1; Xu, Ling-Zhi1; Gao, Lei2; Wang, Xin-Fu3; Zhang, Jing-Tao4; Lu, Lin1
关键词Circadian rhythms Major depressive disorder Escitalopram Clock genes Hormones Peptides
刊名PSYCHONEUROENDOCRINOLOGY
2013-11-01
DOI10.1016/j.psyneuen.2013.07.009
38期:11页:2789-2799
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Neurosciences ; Psychiatry
资助者Natural Science Foundation of China ; Natural Science Foundation of China
研究领域[WOS]Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]I IGF-I ; GROWTH-HORMONE SECRETION ; ENDOGENOUS-DEPRESSION ; BRAIN ; MELATONIN ; CORTISOL ; CLOCK ; RATS ; BIOMARKERS ; WITHDRAWAL
英文摘要

Background: Strong links exist between circadian disturbances and some of the most characteristic symptoms of clinical major depressive disorder (MDD). However, changes in the expression of clock genes or neuropeptides related to the regulation of circadian rhythm that may influence the susceptibility to recurrence after antidepressant treatment in MDD have not been investigated.

Methods: Blood samples were collected at 4 h intervals for 24 h from 12 male healthy controls and 12 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included the relative expression of clock gene mRNA (PERIOD 1, PERIOD2, PERIOD3, CRY1, BMAL1, NPAS2, and GSK-313), and the levels of serum melatonin, vasoactive intestinal polypeptide (VIP), cortisol, adrenocorticotropic hormone (ACTH), insulin-like growth factor-1 (IGF-1), and growth hormone (GH).

Results: Compared with healthy controls, MDD patients showed disruptions in the diurnal rhythms of the expression of PERIOD1, PERIOD2, CRY1, BMAL1, NPAS2, and GSK-3/3 and disruptions in the diurnal rhythms of the release of melatonin, VIP, cortisol, ACTH, IGF-1, and GH. Several of these disruptions (i.e., PERI, CRY1, melatonin, VIP, cortisol, ACTH, and IGF-1) persisted 8 weeks after escitalopram treatment, similar to the increase in the 24 h levels of VIP and decreases in the 24 h levels of cortisol and ACTH.

Conclusion: These persistent neurobiological changes may play a role in MDD symptoms that are thought to contribute to the vulnerability to recurrence and long-term maintenance therapy. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81171251 ; 31230033 ; 91132716
资助者Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号WOS:000328175700040
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67596
专题中国药物依赖性研究所
作者单位1.Rong Jun Hosp, Baoding 071000, Hebei Province, Peoples R China
2.Beijing Daxing Mental Hosp, Beijing 102600, Peoples R China
3.Hosp Psychiat, Jining 272019, Shandong, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Su-Xia,Liu, Li-Jing,Xu, Ling-Zhi,et al. Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment[J]. PSYCHONEUROENDOCRINOLOGY,2013,38(11):2789-2799.
APA Li, Su-Xia.,Liu, Li-Jing.,Xu, Ling-Zhi.,Gao, Lei.,Wang, Xin-Fu.,...&Lu, Lin.(2013).Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment.PSYCHONEUROENDOCRINOLOGY,38(11),2789-2799.
MLA Li, Su-Xia,et al."Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment".PSYCHONEUROENDOCRINOLOGY 38.11(2013):2789-2799.
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