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学科主题: 药物依赖
题名:
Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment
作者: Li, Su-Xia1; Liu, Li-Jing1; Xu, Ling-Zhi1; Gao, Lei2; Wang, Xin-Fu3; Zhang, Jing-Tao4; Lu, Lin1
关键词: Circadian rhythms ; Major depressive disorder ; Escitalopram ; Clock genes ; Hormones ; Peptides
刊名: PSYCHONEUROENDOCRINOLOGY
发表日期: 2013-11-01
DOI: 10.1016/j.psyneuen.2013.07.009
卷: 38, 期:11, 页:2789-2799
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Neurosciences ; Psychiatry
研究领域[WOS]: Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: I IGF-I ; GROWTH-HORMONE SECRETION ; ENDOGENOUS-DEPRESSION ; BRAIN ; MELATONIN ; CORTISOL ; CLOCK ; RATS ; BIOMARKERS ; WITHDRAWAL
英文摘要:

Background: Strong links exist between circadian disturbances and some of the most characteristic symptoms of clinical major depressive disorder (MDD). However, changes in the expression of clock genes or neuropeptides related to the regulation of circadian rhythm that may influence the susceptibility to recurrence after antidepressant treatment in MDD have not been investigated.

Methods: Blood samples were collected at 4 h intervals for 24 h from 12 male healthy controls and 12 male MDD patients before and after treatment with escitalopram for 8 weeks. The outcome measures included the relative expression of clock gene mRNA (PERIOD 1, PERIOD2, PERIOD3, CRY1, BMAL1, NPAS2, and GSK-313), and the levels of serum melatonin, vasoactive intestinal polypeptide (VIP), cortisol, adrenocorticotropic hormone (ACTH), insulin-like growth factor-1 (IGF-1), and growth hormone (GH).

Results: Compared with healthy controls, MDD patients showed disruptions in the diurnal rhythms of the expression of PERIOD1, PERIOD2, CRY1, BMAL1, NPAS2, and GSK-3/3 and disruptions in the diurnal rhythms of the release of melatonin, VIP, cortisol, ACTH, IGF-1, and GH. Several of these disruptions (i.e., PERI, CRY1, melatonin, VIP, cortisol, ACTH, and IGF-1) persisted 8 weeks after escitalopram treatment, similar to the increase in the 24 h levels of VIP and decreases in the 24 h levels of cortisol and ACTH.

Conclusion: These persistent neurobiological changes may play a role in MDD symptoms that are thought to contribute to the vulnerability to recurrence and long-term maintenance therapy. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81171251 ; 31230033 ; 91132716
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000328175700040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67596
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Rong Jun Hosp, Baoding 071000, Hebei Province, Peoples R China
2.Beijing Daxing Mental Hosp, Beijing 102600, Peoples R China
3.Hosp Psychiat, Jining 272019, Shandong, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Li, Su-Xia,Liu, Li-Jing,Xu, Ling-Zhi,et al. Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment[J]. PSYCHONEUROENDOCRINOLOGY,2013,38(11):2789-2799.
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