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学科主题: 基础医学
题名:
Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone
作者: Jia, Haitao1; Tao, Hong1; Feng, Ruopeng2; Li, Meiyu1; Bai, Jie1; Sun, Tao1; Wen, Jinhua2; Hu, Qikuan1
关键词: epidermal growth factor responsive ; neural stem/progenitor cells ; Pax6
刊名: NEUROREPORT
发表日期: 2011-06-22
DOI: 10.1097/WNR.0b013e3283476b46
卷: 22, 期:9, 页:448-452
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBRAL-CORTEX ; SELF-RENEWAL ; IDENTIFICATION ; SPECIFICATION ; PRECURSORS ; FAMILY ; EGFR
英文摘要:

Neural stem/progenitor cells transit from fibroblast growth factor-responsive to epidermal growth factor (EGF)-responsive stem cells in the subventricular zone (SVZ). Here, we provide evidences that Pax6 plays a crucial role in the regulation of the EGF-responsive stem cell pool of the SVZ. Using Pax6 homozygous mutant mice (E18.5d), we found that the neurospheres were formed less than that from the wild-type mice, and the expression of EGF receptor in these neurospheres is downregulated very much. The amount of EGF-responsive cells in the mutant dorsal cortex SVZ (E18.5d) was also decreased from 16.8 (wild) to 4.5% (mutant), by flow cytometry method. Immunostaining of the cortex showed a downregulation of EGF receptor expression. All these results suggest that Pax6 regulate the EGF-responsive stem cells in the SVZ. NeuroReport 22:448-452 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 2011CB966203 ; 30871251 ; 30960150 ; NZ0784.2 ; 20061237
项目资助者: Chinese National 973 Projects ; National Natural Science Foundation of China ; Ningxia Natural Science Foundation ; Ningxia Educational Department
WOS记录号: WOS:000290791400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67603
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Ningxia Med Univ, Dept Physiol, Cranial Cerebral Dis Lab, Ningxia 750004, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Peking Univ Stem Cell Res Ctr, Beijing, Peoples R China

Recommended Citation:
Jia, Haitao,Tao, Hong,Feng, Ruopeng,et al. Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone[J]. NEUROREPORT,2011,22(9):448-452.
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