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学科主题基础医学
Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone
Jia, Haitao1; Tao, Hong1; Feng, Ruopeng2; Li, Meiyu1; Bai, Jie1; Sun, Tao1; Wen, Jinhua2; Hu, Qikuan1
关键词epidermal growth factor responsive neural stem/progenitor cells Pax6
刊名NEUROREPORT
2011-06-22
DOI10.1097/WNR.0b013e3283476b46
22期:9页:448-452
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CEREBRAL-CORTEX ; SELF-RENEWAL ; IDENTIFICATION ; SPECIFICATION ; PRECURSORS ; FAMILY ; EGFR
英文摘要

Neural stem/progenitor cells transit from fibroblast growth factor-responsive to epidermal growth factor (EGF)-responsive stem cells in the subventricular zone (SVZ). Here, we provide evidences that Pax6 plays a crucial role in the regulation of the EGF-responsive stem cell pool of the SVZ. Using Pax6 homozygous mutant mice (E18.5d), we found that the neurospheres were formed less than that from the wild-type mice, and the expression of EGF receptor in these neurospheres is downregulated very much. The amount of EGF-responsive cells in the mutant dorsal cortex SVZ (E18.5d) was also decreased from 16.8 (wild) to 4.5% (mutant), by flow cytometry method. Immunostaining of the cortex showed a downregulation of EGF receptor expression. All these results suggest that Pax6 regulate the EGF-responsive stem cells in the SVZ. NeuroReport 22:448-452 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000290791400008
项目编号2011CB966203 ; 30871251 ; 30960150 ; NZ0784.2 ; 20061237
资助机构Chinese National 973 Projects ; National Natural Science Foundation of China ; Ningxia Natural Science Foundation ; Ningxia Educational Department
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67603
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
作者单位1.Ningxia Med Univ, Dept Physiol, Cranial Cerebral Dis Lab, Ningxia 750004, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Peking Univ Stem Cell Res Ctr, Beijing, Peoples R China
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GB/T 7714
Jia, Haitao,Tao, Hong,Feng, Ruopeng,et al. Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone[J]. NEUROREPORT,2011,22(9):448-452.
APA Jia, Haitao.,Tao, Hong.,Feng, Ruopeng.,Li, Meiyu.,Bai, Jie.,...&Hu, Qikuan.(2011).Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone.NEUROREPORT,22(9),448-452.
MLA Jia, Haitao,et al."Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone".NEUROREPORT 22.9(2011):448-452.
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