北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 细胞生物学系  > 期刊论文
学科主题: 基础医学
题名:
Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone
作者: Jia, Haitao1; Tao, Hong1; Feng, Ruopeng2; Li, Meiyu1; Bai, Jie1; Sun, Tao1; Wen, Jinhua2; Hu, Qikuan1
关键词: epidermal growth factor responsive ; neural stem/progenitor cells ; Pax6
刊名: NEUROREPORT
发表日期: 2011-06-22
DOI: 10.1097/WNR.0b013e3283476b46
卷: 22, 期:9, 页:448-452
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBRAL-CORTEX ; SELF-RENEWAL ; IDENTIFICATION ; SPECIFICATION ; PRECURSORS ; FAMILY ; EGFR
英文摘要:

Neural stem/progenitor cells transit from fibroblast growth factor-responsive to epidermal growth factor (EGF)-responsive stem cells in the subventricular zone (SVZ). Here, we provide evidences that Pax6 plays a crucial role in the regulation of the EGF-responsive stem cell pool of the SVZ. Using Pax6 homozygous mutant mice (E18.5d), we found that the neurospheres were formed less than that from the wild-type mice, and the expression of EGF receptor in these neurospheres is downregulated very much. The amount of EGF-responsive cells in the mutant dorsal cortex SVZ (E18.5d) was also decreased from 16.8 (wild) to 4.5% (mutant), by flow cytometry method. Immunostaining of the cortex showed a downregulation of EGF receptor expression. All these results suggest that Pax6 regulate the EGF-responsive stem cells in the SVZ. NeuroReport 22:448-452 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 2011CB966203 ; 30871251 ; 30960150 ; NZ0784.2 ; 20061237
项目资助者: Chinese National 973 Projects ; National Natural Science Foundation of China ; Ningxia Natural Science Foundation ; Ningxia Educational Department
WOS记录号: WOS:000290791400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67603
Appears in Collections:基础医学院_细胞生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Ningxia Med Univ, Dept Physiol, Cranial Cerebral Dis Lab, Ningxia 750004, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Peking Univ Stem Cell Res Ctr, Beijing, Peoples R China

Recommended Citation:
Jia, Haitao,Tao, Hong,Feng, Ruopeng,et al. Pax6 regulates the epidermal growth factor-responsive neural stem cells of the subventricular zone[J]. NEUROREPORT,2011,22(9):448-452.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jia, Haitao]'s Articles
[Tao, Hong]'s Articles
[Feng, Ruopeng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jia, Haitao]‘s Articles
[Tao, Hong]‘s Articles
[Feng, Ruopeng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace