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学科主题: 基础医学
题名:
Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice
作者: Deng, WN; Han, Q; Liao, LM; You, SG; Deng, HY; Zhao, RCH
刊名: DNA AND CELL BIOLOGY
发表日期: 2005-07-01
卷: 24, 期:7, 页:458-463
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INTERFERON-GAMMA ; IMMUNOLOGICAL-PROPERTIES ; AUTOIMMUNE-DISEASE ; EXPRESSION ; INHIBIT ; INTERLEUKIN-4
英文摘要:

Bone marrow-derived mesenchymal stem cells (bMSCs) can differentiate into a number of different cell/tissue types, and also possess immunoregulatory functions. The present study was undertaken to elucidate the exact immunoregulatory effects of allogeneic bMSCs on T- and B-lymphocyte proliferation, activation, and function maturation of BXSB mice, which has been considered as a experimental model for human systemic lupus erythematosus (SLE). We determined that bMSCs from BALB/c mice had inhibitory effects on BXSB mice T- lymphocyte proliferation, but no inhibitory effect on their activation. In addition, they had a significant inhibitory and stimulatory effect on IL-4- and IFN-gamma-producing T cells, respectively. Also, bMSCs had inhibitory effects on the proliferation, activation, and IgG secretion of B lymphocytes. In addition, BALB/c bMSCs had an enhancing effect on CD40 expression and inhibitory effects on CD40 ligand (CD40L) ectopic hyperexpression on B cells from BXSB mice.

语种: 英语
WOS记录号: WOS:000230586300006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67604
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Ctr Tissue Engn, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing, Peoples R China
4.Tianjin Med Univ, Dept Immunol, Tianjin, Peoples R China

Recommended Citation:
Deng, WN,Han, Q,Liao, LM,et al. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice[J]. DNA AND CELL BIOLOGY,2005,24(7):458-463.
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