IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice
Deng, WN; Han, Q; Liao, LM; You, SG; Deng, HY; Zhao, RCH
刊名DNA AND CELL BIOLOGY
2005-07-01
24期:7页:458-463
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Genetics & Heredity
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INTERFERON-GAMMA ; IMMUNOLOGICAL-PROPERTIES ; AUTOIMMUNE-DISEASE ; EXPRESSION ; INHIBIT ; INTERLEUKIN-4
英文摘要

Bone marrow-derived mesenchymal stem cells (bMSCs) can differentiate into a number of different cell/tissue types, and also possess immunoregulatory functions. The present study was undertaken to elucidate the exact immunoregulatory effects of allogeneic bMSCs on T- and B-lymphocyte proliferation, activation, and function maturation of BXSB mice, which has been considered as a experimental model for human systemic lupus erythematosus (SLE). We determined that bMSCs from BALB/c mice had inhibitory effects on BXSB mice T- lymphocyte proliferation, but no inhibitory effect on their activation. In addition, they had a significant inhibitory and stimulatory effect on IL-4- and IFN-gamma-producing T cells, respectively. Also, bMSCs had inhibitory effects on the proliferation, activation, and IgG secretion of B lymphocytes. In addition, BALB/c bMSCs had an enhancing effect on CD40 expression and inhibitory effects on CD40 ligand (CD40L) ectopic hyperexpression on B cells from BXSB mice.

语种英语
WOS记录号WOS:000230586300006
Citation statistics
Cited Times:91[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67604
Collection北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Ctr Tissue Engn, Beijing 100037, Peoples R China
3.Peking Union Med Coll, Beijing, Peoples R China
4.Tianjin Med Univ, Dept Immunol, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Deng, WN,Han, Q,Liao, LM,et al. Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice[J]. DNA AND CELL BIOLOGY,2005,24(7):458-463.
APA Deng, WN,Han, Q,Liao, LM,You, SG,Deng, HY,&Zhao, RCH.(2005).Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice.DNA AND CELL BIOLOGY,24(7),458-463.
MLA Deng, WN,et al."Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice".DNA AND CELL BIOLOGY 24.7(2005):458-463.
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