北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 内分泌内科  > 期刊论文
学科主题: 临床医学
题名:
The expression of Fc gamma receptors in Hashimoto′s thyroiditis
作者: Liu, Yalei1; Liu, Mingming2; Zhang, Yang1; Qu, Chenxue3; Lu, Guizhi1; Huang, Youyuan1; Zhang, Hong1; Yu, Nan1; Yuan, Shanshan1; Gao, Ying1; Gao, Yanming1; Guo, Xiaohui1
关键词: Hashimoto&prime ; s thyroiditis ; Fc gamma Rs ; Fc gamma RIIB ; B cells
刊名: CELLULAR IMMUNOLOGY
发表日期: 2015-03-01
DOI: 10.1016/j.cellimm.2015.01.016
卷: 294, 期:1, 页:33-38
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: MEMORY B-CELLS ; RHEUMATOID-ARTHRITIS ; IMMUNOGLOBULIN-G ; FUNCTIONAL STATUS ; LUPUS NEPHRITIS ; DOWN-REGULATION ; LYMPHOCYTES-B ; AUTOANTIBODIES ; ANTIBODY ; DISEASE
英文摘要:

The pathophysiological mechanism underlying Hashimoto′s thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are diagnostic hallmarks of HT. These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fc gamma receptors (Fc gamma Rs). The aim of our study was to investigate the role of Fc gamma Rs in the pathogenesis of HT. The percentage of peripheral blood mononuclear cells (PBMCs) from HT patients bearing Fc gamma RII was significantly lower than that seen in healthy donors, and the mean fluorescence intensity (MFI) value of Fc gamma RII on PBMCs from HT patients was significantly higher. The percentage of PBMCs positive for Fc gamma RIII also was significantly higher in HT patients, and the percentage of B cells bearing Fc gamma RIIB in HT patients was significantly lower than that seen in healthy donors. Our study therefore provides evidence for Fc gamma Rs, especially Fc gamma RIIB, being involved in the pathogenesis of HT. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81370887 ; BMU20110266 ; 2011011 ; 7122185
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Nova Program ; Beijing Natural Science Foundation
WOS记录号: WOS:000350188000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67608
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
2.Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Yalei,Liu, Mingming,Zhang, Yang,et al. The expression of Fc gamma receptors in Hashimoto′s thyroiditis[J]. CELLULAR IMMUNOLOGY,2015,294(1):33-38.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Yalei]'s Articles
[Liu, Mingming]'s Articles
[Zhang, Yang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Yalei]‘s Articles
[Liu, Mingming]‘s Articles
[Zhang, Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace