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学科主题临床医学
The expression of Fc gamma receptors in Hashimoto′s thyroiditis
Liu, Yalei1; Liu, Mingming2; Zhang, Yang1; Qu, Chenxue3; Lu, Guizhi1; Huang, Youyuan1; Zhang, Hong1; Yu, Nan1; Yuan, Shanshan1; Gao, Ying1; Gao, Yanming1; Guo, Xiaohui1
关键词Hashimoto&prime s thyroiditis Fc gamma Rs Fc gamma RIIB B cells
刊名CELLULAR IMMUNOLOGY
2015-03-01
DOI10.1016/j.cellimm.2015.01.016
294期:1页:33-38
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]MEMORY B-CELLS ; RHEUMATOID-ARTHRITIS ; IMMUNOGLOBULIN-G ; FUNCTIONAL STATUS ; LUPUS NEPHRITIS ; DOWN-REGULATION ; LYMPHOCYTES-B ; AUTOANTIBODIES ; ANTIBODY ; DISEASE
英文摘要

The pathophysiological mechanism underlying Hashimoto′s thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are diagnostic hallmarks of HT. These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fc gamma receptors (Fc gamma Rs). The aim of our study was to investigate the role of Fc gamma Rs in the pathogenesis of HT. The percentage of peripheral blood mononuclear cells (PBMCs) from HT patients bearing Fc gamma RII was significantly lower than that seen in healthy donors, and the mean fluorescence intensity (MFI) value of Fc gamma RII on PBMCs from HT patients was significantly higher. The percentage of PBMCs positive for Fc gamma RIII also was significantly higher in HT patients, and the percentage of B cells bearing Fc gamma RIIB in HT patients was significantly lower than that seen in healthy donors. Our study therefore provides evidence for Fc gamma Rs, especially Fc gamma RIIB, being involved in the pathogenesis of HT. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000350188000006
项目编号81370887 ; BMU20110266 ; 2011011 ; 7122185
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Nova Program ; Beijing Natural Science Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67608
专题北京大学第一临床医学院_内分泌内科
作者单位1.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
2.Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Liu, Yalei,Liu, Mingming,Zhang, Yang,et al. The expression of Fc gamma receptors in Hashimoto′s thyroiditis[J]. CELLULAR IMMUNOLOGY,2015,294(1):33-38.
APA Liu, Yalei.,Liu, Mingming.,Zhang, Yang.,Qu, Chenxue.,Lu, Guizhi.,...&Guo, Xiaohui.(2015).The expression of Fc gamma receptors in Hashimoto′s thyroiditis.CELLULAR IMMUNOLOGY,294(1),33-38.
MLA Liu, Yalei,et al."The expression of Fc gamma receptors in Hashimoto′s thyroiditis".CELLULAR IMMUNOLOGY 294.1(2015):33-38.
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