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学科主题: 临床医学
题名:
Plasma resistin associated with myocardium injury in patients with acute coronary syndrome
作者: Chu, Songyun1; Ding, Wenhui1; Li, Kang2; Pang, Yongzheng3; Tang, Chaoshu3
关键词: acute coronary syndrome ; resistin
刊名: CIRCULATION JOURNAL
发表日期: 2008-08-01
卷: 72, 期:8, 页:1249-1253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: SERUM RESISTIN ; INSULIN-RESISTANCE ; ARTERY-DISEASE ; EXPRESSION ; HUMANS ; ACTIVATION ; PROGNOSIS ; OBESITY ; MARKER
英文摘要:

Background Resistin, a novel adipocytokine, has been suggested as representing a link between metabolic signals, inflammation and atherosclerosis. The aim of the present study was to investigate the alteration in level of plasma resistin in patients with acute coronary syndrome (ACS) to uncover the role of resistin.

Methods and Results The 39 patients with ACS and 26 age-matched healthy subjects in this cross-sectional Study were investigated. Plasma resistin levels were measured using radioimmunoassay. Plasma resistin levels were significantly increased in patients with ACS at 24h after symptoms onset and remained at a high level for week, and were significantly higher in patients with acute myocardial infarction than in those with unstable angina. In addition, plasma resistin level was correlated positively with peak plasma creatine kinase (CK), the MB isoform of CK and troponin 1, and was correlated negatively with left ventricular ejection fraction. No correlation was found beween plasma resistin level with level of metabolic parameters or inflammatory markers.

Conclusions Plasma resistin levels in patients with ACS are elevated significantly within the first week after symptoms onset. Increased resistin levels may be a marker of myocardial ischemia and injury in ACS.

语种: 英语
WOS记录号: WOS:000258054600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67609
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Beijing Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathol, Beijing 100034, Peoples R China

Recommended Citation:
Chu, Songyun,Ding, Wenhui,Li, Kang,et al. Plasma resistin associated with myocardium injury in patients with acute coronary syndrome[J]. CIRCULATION JOURNAL,2008,72(8):1249-1253.
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