IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Plasma resistin associated with myocardium injury in patients with acute coronary syndrome
Chu, Songyun1; Ding, Wenhui1; Li, Kang2; Pang, Yongzheng3; Tang, Chaoshu3
关键词acute coronary syndrome resistin
刊名CIRCULATION JOURNAL
2008-08-01
72期:8页:1249-1253
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]SERUM RESISTIN ; INSULIN-RESISTANCE ; ARTERY-DISEASE ; EXPRESSION ; HUMANS ; ACTIVATION ; PROGNOSIS ; OBESITY ; MARKER
英文摘要

Background Resistin, a novel adipocytokine, has been suggested as representing a link between metabolic signals, inflammation and atherosclerosis. The aim of the present study was to investigate the alteration in level of plasma resistin in patients with acute coronary syndrome (ACS) to uncover the role of resistin.

Methods and Results The 39 patients with ACS and 26 age-matched healthy subjects in this cross-sectional Study were investigated. Plasma resistin levels were measured using radioimmunoassay. Plasma resistin levels were significantly increased in patients with ACS at 24h after symptoms onset and remained at a high level for week, and were significantly higher in patients with acute myocardial infarction than in those with unstable angina. In addition, plasma resistin level was correlated positively with peak plasma creatine kinase (CK), the MB isoform of CK and troponin 1, and was correlated negatively with left ventricular ejection fraction. No correlation was found beween plasma resistin level with level of metabolic parameters or inflammatory markers.

Conclusions Plasma resistin levels in patients with ACS are elevated significantly within the first week after symptoms onset. Increased resistin levels may be a marker of myocardial ischemia and injury in ACS.

语种英语
WOS记录号WOS:000258054600007
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67609
专题北京大学第一临床医学院_心血管内科
作者单位1.Beijing Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chu, Songyun,Ding, Wenhui,Li, Kang,et al. Plasma resistin associated with myocardium injury in patients with acute coronary syndrome[J]. CIRCULATION JOURNAL,2008,72(8):1249-1253.
APA Chu, Songyun,Ding, Wenhui,Li, Kang,Pang, Yongzheng,&Tang, Chaoshu.(2008).Plasma resistin associated with myocardium injury in patients with acute coronary syndrome.CIRCULATION JOURNAL,72(8),1249-1253.
MLA Chu, Songyun,et al."Plasma resistin associated with myocardium injury in patients with acute coronary syndrome".CIRCULATION JOURNAL 72.8(2008):1249-1253.
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