|Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome|
|Wang, L.; Peng, L.; Dong, B.; Kong, L.; Meng, L.; Yan, L.; Xie, Y.; Shou, C.|
|关键词||breast cancer PRL-3 prognosis|
|刊名||ANNALS OF ONCOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||TYROSINE-PHOSPHATASE ; COLORECTAL-CANCER ; PRL-3 PHOSPHATASE ; CYCLIN-E ; METASTASIS ; EXPRESSION ; PROTEIN ; MOTILITY ; CELLS ; INVASION|
Background: Increasing evidence has suggested that phosphatase of regenerating liver-3 (PRL-3) plays an important role in cancer cell migration, invasion and metastasis. However, the correlation between the PRL-3 expression and clinical outcome in breast cancer has not been investigated.
Patients and methods: Using a PRL-3-specific monoclonal antibody 3B6, PRL-3 expression was assessed by immunohistochemistry in tumor tissues from 382 breast cancer patients with a median follow-up of 65 months.
Results: We found that 34.8% patients expressed a high level of PRL-3 protein in their tumors. Patients with a high level of PRL-3 in the tumor had a worse disease-specific survival (DSS) rate than those with a low level of PRL-3 (74.0% versus 84.9%, P = 0.011), and PRL-3 remained an independent prognostic marker for DSS (HR 1.8, 95% CI 1.1-2.9, P = 0.019) in multivariate analysis. More importantly, in 219 node-negative patients, PRL-3 showed a significant correlation with DSS in univariate analysis (P = 0.014) and retained a borderline significance (HR 2.65, 95% CI 0.92-7.64, P = 0.071) in multivariate analysis.
Conclusions: Our results suggest that PRL-3 may serve as an unfavorable prognostic marker in breast cancer, especially for patients with node-negative diseases. Thus, our findings may provide useful information for individualized therapy in the clinical setting.
|作者单位||1.People Hosp Henan Prov, Zhengzhou, HeNan, Peoples R China|
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Breast Ctr, Beijing 100036, Peoples R China
|Wang, L.,Peng, L.,Dong, B.,et al. Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome[J]. ANNALS OF ONCOLOGY,2006,17(10):1517-1522.|
|APA||Wang, L..,Peng, L..,Dong, B..,Kong, L..,Meng, L..,...&Shou, C..(2006).Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome.ANNALS OF ONCOLOGY,17(10),1517-1522.|
|MLA||Wang, L.,et al."Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome".ANNALS OF ONCOLOGY 17.10(2006):1517-1522.|