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学科主题: 临床医学
题名:
Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome
作者: Wang, L.; Peng, L.; Dong, B.; Kong, L.; Meng, L.; Yan, L.; Xie, Y.; Shou, C.
关键词: breast cancer ; PRL-3 ; prognosis
刊名: ANNALS OF ONCOLOGY
发表日期: 2006-10-01
DOI: 10.1093/annonc/mdl159
卷: 17, 期:10, 页:1517-1522
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TYROSINE-PHOSPHATASE ; COLORECTAL-CANCER ; PRL-3 PHOSPHATASE ; CYCLIN-E ; METASTASIS ; EXPRESSION ; PROTEIN ; MOTILITY ; CELLS ; INVASION
英文摘要:

Background: Increasing evidence has suggested that phosphatase of regenerating liver-3 (PRL-3) plays an important role in cancer cell migration, invasion and metastasis. However, the correlation between the PRL-3 expression and clinical outcome in breast cancer has not been investigated.

Patients and methods: Using a PRL-3-specific monoclonal antibody 3B6, PRL-3 expression was assessed by immunohistochemistry in tumor tissues from 382 breast cancer patients with a median follow-up of 65 months.

Results: We found that 34.8% patients expressed a high level of PRL-3 protein in their tumors. Patients with a high level of PRL-3 in the tumor had a worse disease-specific survival (DSS) rate than those with a low level of PRL-3 (74.0% versus 84.9%, P = 0.011), and PRL-3 remained an independent prognostic marker for DSS (HR 1.8, 95% CI 1.1-2.9, P = 0.019) in multivariate analysis. More importantly, in 219 node-negative patients, PRL-3 showed a significant correlation with DSS in univariate analysis (P = 0.014) and retained a borderline significance (HR 2.65, 95% CI 0.92-7.64, P = 0.071) in multivariate analysis.

Conclusions: Our results suggest that PRL-3 may serve as an unfavorable prognostic marker in breast cancer, especially for patients with node-negative diseases. Thus, our findings may provide useful information for individualized therapy in the clinical setting.

语种: 英语
WOS记录号: WOS:000240926200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67610
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.People Hosp Henan Prov, Zhengzhou, HeNan, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Pathol, Beijing 100036, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Breast Ctr, Beijing 100036, Peoples R China

Recommended Citation:
Wang, L.,Peng, L.,Dong, B.,et al. Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome[J]. ANNALS OF ONCOLOGY,2006,17(10):1517-1522.
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