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学科主题: 口腔医学
题名:
Clear cell odontogenic carcinoma - A clinicopathologic and immunocytochemical study of 5 cases
作者: Li, TJ; Yu, SF; Gao, Y; Wang, EB
刊名: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
发表日期: 2001-12-01
卷: 125, 期:12, 页:1566-1571
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]: Medical Laboratory Technology ; Research & Experimental Medicine ; Pathology
关键词[WOS]: LYMPH-NODE METASTASIS ; SALIVARY-GLANDS ; MALIGNANT-MELANOMA ; SOFT PARTS ; TOOTH GERM ; AMELOBLASTOMA ; TUMORS ; VARIANT ; DIFFERENTIATION ; EXPRESSION
英文摘要:

Context.-Odontogenic tumor composed predominantly of clear cells is a rare neoplasm of the jaws that was initially designated as clear cell odontogenic tumor. Subsequent reports in the literature, however, all have indicated that this tumor exhibits an aggressive behavior characterized by infiltrative local growth, recurrence, or metastases.

Objective.-To ascertain the clinicomorphologic features and biologic behavior of this tumor group, we present 5 additional cases using the term clear cell odontogenic carcinoma.

Design.-Histologic and immunohistochemical examinations were performed on clear cell odontogenic carcinomas from 5 patients. Clinical and follow-up data were recorded, and the literature was reviewed.

Results.-The patients were 1 man and 4 women with an average age of 42.4 years at diagnosis. Three tumors occurred in the mandible and the other 2 in the maxilla. Four of the 5 cases occurred in the anterior or premolar areas of the jaws, appearing as poorly marginated radio-lucencies. All cases consisted of islands and sheets of large clear cells and small basaloid cells with scanty eosinophilic cytoplasm, which were separated by thin, mature, fibrous septae. The tumors were unencapsulated and showed aggressive infiltration of the surrounding muscle and perineural tissues. Most of the clear cells contained cytoplasmic glycogen. Immunocytochemically, the tumor cells were positive for pan-keratin, cytokeratin 19, and epithelial membrane antigen, but were negative for vimentin, S100 protein, desmin, smooth muscle actin, human melanoma antigen (HMB-45), and alpha (1)-antichymotrypsin. Follow-up data showed 4 of 5 patients to have multiple local recurrences, and I of these 4 had submandibular lymph node metastasis and a fatal outcome due to uncontrollable tumor growth.

Conclusion.-These results suggest that odontogenic clear cell neoplasms are at least low-grade malignancies and should be classified as carcinomas.

语种: 英语
WOS记录号: WOS:000172793000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67615
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Li, TJ,Yu, SF,Gao, Y,et al. Clear cell odontogenic carcinoma - A clinicopathologic and immunocytochemical study of 5 cases[J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE,2001,125(12):1566-1571.
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