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学科主题: 药学
题名:
Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers
作者: Li, Q; Guan, HZ; Pu, XP
关键词: annexin V ; antibody ; ion trap mass spectrometry ; liquid chromatography ; neuropathy
刊名: NEUROREPORT
发表日期: 2004-09-15
卷: 15, 期:13, 页:2083-2087
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: SYSTEMIC LUPUS-ERYTHEMATOSUS ; TANDEM MASS-SPECTROMETRY ; ANNEXIN-V ; CLINICAL-SIGNIFICANCE ; RHEUMATOID-ARTHRITIS ; COMPLEXES ; MIXTURES ; ANTIBODIES ; GELS
英文摘要:

A 35 kDa protein was purified from rat spinal ganglia and sensory fibers. Combined direct trypsin digest and liquid chromatography ion trap mass spectrometry analysis, the 35 kDa protein was identified as annexin V. We then studied the distribution of serum antibodies to annexin V in patients with peripheral neuropathy. We found serum positive antibodies to annexin V only in some patients with immune-mediated neuropathy. This indicated that humoral immune responses to annexin V might play a role in the pathogenesis of autoimmune sensory neuropathy or sensory neuronopathy.

语种: 英语
WOS记录号: WOS:000225141200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67622
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Coll Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China

Recommended Citation:
Li, Q,Guan, HZ,Pu, XP. Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers[J]. NEUROREPORT,2004,15(13):2083-2087.
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