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Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers
Li, Q; Guan, HZ; Pu, XP
关键词annexin V antibody ion trap mass spectrometry liquid chromatography neuropathy
刊名NEUROREPORT
2004-09-15
15期:13页:2083-2087
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SYSTEMIC LUPUS-ERYTHEMATOSUS ; TANDEM MASS-SPECTROMETRY ; ANNEXIN-V ; CLINICAL-SIGNIFICANCE ; RHEUMATOID-ARTHRITIS ; COMPLEXES ; MIXTURES ; ANTIBODIES ; GELS
英文摘要

A 35 kDa protein was purified from rat spinal ganglia and sensory fibers. Combined direct trypsin digest and liquid chromatography ion trap mass spectrometry analysis, the 35 kDa protein was identified as annexin V. We then studied the distribution of serum antibodies to annexin V in patients with peripheral neuropathy. We found serum positive antibodies to annexin V only in some patients with immune-mediated neuropathy. This indicated that humoral immune responses to annexin V might play a role in the pathogenesis of autoimmune sensory neuropathy or sensory neuronopathy.

语种英语
WOS记录号WOS:000225141200017
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67622
专题北京大学药学院
作者单位1.Peking Univ, Coll Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
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GB/T 7714
Li, Q,Guan, HZ,Pu, XP. Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers[J]. NEUROREPORT,2004,15(13):2083-2087.
APA Li, Q,Guan, HZ,&Pu, XP.(2004).Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers.NEUROREPORT,15(13),2083-2087.
MLA Li, Q,et al."Identification of a 35 kDa protein in rat spinal ganglia and sensory fibers".NEUROREPORT 15.13(2004):2083-2087.
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