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学科主题: 临床医学
题名:
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease
作者: Wang, Hai-Ning; Wang, Yan-Rong; Liu, Guo-Qiang; Liu, Zhe; Wu, Pei-Xian; Wei, Xiao-Ling; Hong, Tian-Pei
关键词: Insulin resistance ; Interleukin-18 ; Non-alcoholic fatty liver ; Rosiglitazone
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2008-12-21
DOI: 10.3478/wjg.14.7240
卷: 14, 期:47, 页:7240-7246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: POLYCYSTIC-OVARY-SYNDROME ; GAMMA-INDUCING FACTOR ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; TNF-ALPHA ; PLASMA INTERLEUKIN-18 ; INFLAMMATORY MARKERS ; POTENTIAL MECHANISM ; WEIGHT-LOSS ; STEATOHEPATITIS
英文摘要:

AIM: To investigate the effects of rosiglitazone (RGZ) on expression of interleukin-18 (IL-18) and caspase-1 in liver of non-alcoholic fatty liver disease (NAFLD) rats.

METHODS: Twenty-eight Sprague-Dawley (SD) rats were randomly divided into control, NAFLD, and RGZ treated NAFLD groups. A NAFLD rat model of NAFLD was established by feeding the animals with a high-fat diet for 12 wk. The NAFLD animals were treated with RGZ or vehicle for the last 4 wk (week 9-12) and then sacrificed to obtain liver tissues. Histological changes were analyzed with HE, oil red 0 and Masson′s trichrome staining. Expressions of IL-18 and caspase-1 were detected using immunohistochemical staining and semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) analysis.

RESULTS: The expression levels of both IL-18 and caspase-1 were higher in the liver of NAFLD group than in the control group. Steatosis, inflammation and fibrosis, found in the liver of NAFLD rats, were significantly improved 4 wk after RGZ treatment. The elevated hepatic IL-18 and caspase-1 expressions in NAFLD group were also significantly attenuated after RGZ treatment.

CONCLUSION: RGZ treatment can ameliorate increased hepatic IL-18 production and histological changes in liver of NAFLD rats. The beneficial effects of RGZ on NAFLD may be partly due to its inhibitory effect on hepatic IL-18 production. (C) 2008 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000262056500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67625
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Hai-Ning,Wang, Yan-Rong,Liu, Guo-Qiang,et al. Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(47):7240-7246.
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