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学科主题: 药学
题名:
Stereoselective Synthesis of the C-5-C-18 Fragment of Halichomycin
作者: Li, Qingjiang1; Mao, Shiyong1; Cui, Yuxin1; Jia, Yanxing1,2
刊名: JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2012-04-20
DOI: 10.1021/jo202602n
卷: 77, 期:8, 页:4111-4116
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: BAEYER-VILLIGER OXIDATION ; EFFICIENT TOTAL-SYNTHESIS ; ASYMMETRIC-SYNTHESIS ; GAMMA-HYDROXY-ALPHA,BETA-ACETYLENIC ESTERS ; ENANTIOSELECTIVE SYNTHESIS ; ACID ; CYCLOHEXANONES ; METHYL ; UNIT
英文摘要:

An efficient and convergent synthesis of the C-5-C-18 fragment of halichomycin is reported. Butanolide fragment 6 was readily prepared stereoselectively from (R)-Roche ester through catalyst control; dienylic bromide domain 7 was synthesized from (S)-serine by substrate control. C-5-C-18 fragment 2 was rapidly assembled through a stereoselective alkylation of the butanolide with the dienylic bromide, followed by functional group transformations.

语种: 英语
所属项目编号: 20972007 ; 20802005 ; 2010CB833200
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; NCET
WOS记录号: WOS:000302982000041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67627
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

Recommended Citation:
Li, Qingjiang,Mao, Shiyong,Cui, Yuxin,et al. Stereoselective Synthesis of the C-5-C-18 Fragment of Halichomycin[J]. JOURNAL OF ORGANIC CHEMISTRY,2012,77(8):4111-4116.
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