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Signal pathways involved in the biological effects of sulfur dioxide
Wang, Xin-Bao1; Du, Jun-Bao2; Cui, Hong1
关键词Sulfur dioxide Gasotransmitter Signal pathway Biology
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2015-10-05
DOI10.1016/j.ejphar.2015.06.044
764页:94-99
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]INDUCED MYOCARDIAL INJURY ; CARDIOVASCULAR-SYSTEM ; PULMONARY-HYPERTENSION ; OXIDATIVE STRESS ; HYDROGEN-SULFIDE ; SERUM SULFITE ; RATS ; DERIVATIVES ; METABOLISM ; DAMAGE
英文摘要

Gasotransmitters, such as nitric oxide, carbon monoxide and hydrogen sulfide, play important roles in life and have attracted great interest in scientists. In recent years, sulfur dioxide (SO2) has also been found to play important roles in mammals. The redox pathway is involved in the biological effects of SO2, such as the protective effect on myocardial ischemia reperfusion, myocardial injury, pulmonary hypertension and atherosclerosis. Ion channels, such as L-type calcium and adenosine triphosphate-sensitive potassium channels, as well as 3′-5′-cyclic guanosine monophosphate and 3′-5′-cyclic adenosine monophosphate pathways are also involved in the vasorelaxant effect of SO2. The mitogen-activated protein kinase pathway plays roles in vascular remodeling during pulmonary hypertension and vascular smooth muscle cell proliferation. Understanding these signaling mechanisms would help to clarify the pathophysiological effect and therapeutic potential of SO2. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000362987800012
项目编号81441009
资助机构National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67632
专题北京大学第一临床医学院_儿科
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing 100050, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
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Wang, Xin-Bao,Du, Jun-Bao,Cui, Hong. Signal pathways involved in the biological effects of sulfur dioxide[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,764:94-99.
APA Wang, Xin-Bao,Du, Jun-Bao,&Cui, Hong.(2015).Signal pathways involved in the biological effects of sulfur dioxide.EUROPEAN JOURNAL OF PHARMACOLOGY,764,94-99.
MLA Wang, Xin-Bao,et al."Signal pathways involved in the biological effects of sulfur dioxide".EUROPEAN JOURNAL OF PHARMACOLOGY 764(2015):94-99.
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