北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Signal pathways involved in the biological effects of sulfur dioxide
作者: Wang, Xin-Bao1; Du, Jun-Bao2; Cui, Hong1
关键词: Sulfur dioxide ; Gasotransmitter ; Signal pathway ; Biology
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2015-10-05
DOI: 10.1016/j.ejphar.2015.06.044
卷: 764, 页:94-99
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INDUCED MYOCARDIAL INJURY ; CARDIOVASCULAR-SYSTEM ; PULMONARY-HYPERTENSION ; OXIDATIVE STRESS ; HYDROGEN-SULFIDE ; SERUM SULFITE ; RATS ; DERIVATIVES ; METABOLISM ; DAMAGE
英文摘要:

Gasotransmitters, such as nitric oxide, carbon monoxide and hydrogen sulfide, play important roles in life and have attracted great interest in scientists. In recent years, sulfur dioxide (SO2) has also been found to play important roles in mammals. The redox pathway is involved in the biological effects of SO2, such as the protective effect on myocardial ischemia reperfusion, myocardial injury, pulmonary hypertension and atherosclerosis. Ion channels, such as L-type calcium and adenosine triphosphate-sensitive potassium channels, as well as 3′-5′-cyclic guanosine monophosphate and 3′-5′-cyclic adenosine monophosphate pathways are also involved in the vasorelaxant effect of SO2. The mitogen-activated protein kinase pathway plays roles in vascular remodeling during pulmonary hypertension and vascular smooth muscle cell proliferation. Understanding these signaling mechanisms would help to clarify the pathophysiological effect and therapeutic potential of SO2. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81441009
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000362987800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67632
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing 100050, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Xin-Bao,Du, Jun-Bao,Cui, Hong. Signal pathways involved in the biological effects of sulfur dioxide[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,764:94-99.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Xin-Bao]'s Articles
[Du, Jun-Bao]'s Articles
[Cui, Hong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Xin-Bao]‘s Articles
[Du, Jun-Bao]‘s Articles
[Cui, Hong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace