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CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion
Qiu, Bin1; Hu, Shengdi1; Liu, Libing2; Chen, Man1; Wang, Lai1; Zeng, Xianwei2; Zhu, Shigong1
关键词CART BDNF CREB Cerebral ischemia Endoplasmic reticulum stress Neuron
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-07-12
DOI10.1016/j.bbrc.2013.05.142
436期:4页:655-659
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; Major National Basic Research Grant of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; Major National Basic Research Grant of China
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NEUROTROPHIC FACTOR ; ERK ACTIVATION ; CELL-DEATH ; STROKE ; BRAIN ; TRANSCRIPT ; PROTECTS ; NEUROPROTECTION ; EXPRESSION ; CASPASE-12
英文摘要

Cocaine and amphetamine regulated transcript (CART), a neuropeptide, has shown strong neuroprotective effects against cerebral ischemia and reperfusion (I/R) injury in vivo and in vitro. Here, we report a new effect of CART on ER stress which is induced by cerebral I/R in a rat model of middle cerebral artery occlusion (MCAO) or by oxygen and glucose deprivation (OGD) in cultured cortical neurons, as well as a new functionality of BDNF in the neuroprotection by CART against the ER stress in cerebral I/R. The results showed that CART was effective in reducing the neuronal apoptosis and expression of ER stress markers (GRP78, CHOP and cleaved caspase12), and increasing the BDNF expression in I/R injury rat cortex both in vivo and in vitro. In addition, the effects of CART on ischemia-induced neuronal apoptosis and ER stress were suppressed by tyrosine receptor kinase B (TrkB) IgG, whereas the effects of CART on BDNF transcription, synthesis and secretion were abolished by CREB siRNA. This work suggests that CART is functional in inhibiting the cerebral I/R-induced ER stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of BDNF in a CREB-dependent way. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81171081 ; 20090001110060 ; 2010CB912504
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; Major National Basic Research Grant of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; Major National Basic Research Grant of China
WOS记录号WOS:000322415400016
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67640
专题基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Weifang Med Univ, Dept Anesthesiol, Weifang, Shandong, Peoples R China
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GB/T 7714
Qiu, Bin,Hu, Shengdi,Liu, Libing,et al. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,436(4):655-659.
APA Qiu, Bin.,Hu, Shengdi.,Liu, Libing.,Chen, Man.,Wang, Lai.,...&Zhu, Shigong.(2013).CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,436(4),655-659.
MLA Qiu, Bin,et al."CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436.4(2013):655-659.
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