IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis
Lu, X. -L.1,2,3,4; Najafzadeh, M. J.5,6; Dolatabadi, S.1; Ran, Y. -P.7; van den Ende, A. H. G. Gerrits1; Shen, Y. -N.3,4; Li, C. -Y.8; Xi, L. -Y.9; Hao, F.10; Zhang, Q. -Q.11; Li, R. -Y.12; Hu, Z. -M.13; Lu, G. -X.3,4; Wang, J. -J.9; Drogari-Apiranthitou, M.14; Klaassen, C.15; Meis, J. F.15; Hagen, F.15; Liu, W. -D.2,3,4; de Hoog, G. S.1,9,12,16
关键词biodiversity chronic cutaneous infection epidemiology Mucor hiemalis Mucor irregularis Mucormycosis taxonomy
刊名PERSOONIA
2013-06-01
DOI10.3767/003158513X665539
30页:48-56
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]RHIZOMUCOR-VARIABILIS ; EXTRACELLULAR LIPASE ; RHIZOPUS-ORYZAE ; IDENTIFICATION ; PHYCOMYCOSIS ; ZYGOMYCOSIS ; PHYLOGENY ; INFECTION ; ELEGANS ; WEHMER
英文摘要

Mucormycosis usually presents as a progressive infection with significant angio-invasion. Mucormycosis due to Mucor irregularis (formerly Rhizomucor variabilis var. variabilis), however, is exceptional in causing chronic cutaneous infection in immunocompetent humans, ultimately leading to severe morbidity if left untreated. More than 90 % of the cases known to date were reported from Asia, mainly from China. The nearest neighbour of M. irregularis is the saprobic species M. hiemalis. The aim of this study was to evaluate the taxonomic position, epidemiology, and intra-and inter-species diversity of M. irregularis based on 21 strains (clinical n = 17) by multilocus analysis using ITS, LSU, RPB1 and RPB2 genes, compared to results of cluster analysis with amplified fragment length polymorphism (AFLP) data. By combining MLST and AFLP analyses, M. irregularis was found to be monophyletic with high bootstrap support, and consisted of five subgroups, which were not concordant in all partitions. It was thus confirmed that M. irregularis is a single species at 96.1-100 % ITS similarity and low recombination rates between populations. Some geographic structuring was noted with some localised populations, which may be explained by limited air-dispersal. The natural habitat of the species is likely to be in soil and decomposing plant material.

语种英语
WOS记录号WOS:000317399800004
项目编号11CDP009 ; 81101232
资助机构China Desk of KNAW project ; National Natural Sciences Foundation of China
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67647
专题北京大学第一临床医学院_皮肤性病科
作者单位1.CBS KNAW Fungal Biodivers Ctr, NL-3584 CT Utrecht, Netherlands
2.Dalian Med Univ, Dept Mycol, Dermatol Hosp Dalian, Dalian, Peoples R China
3.Chinese Acad Med Sci, Dept Mycol, Inst Dermatol, Nanjing, Jiangsu, Peoples R China
4.Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China
5.Mashhad Univ Med Sci, Dept Parasitol & Mycol, Ghaem Hosp, Sch Med, Mashhad, Iran
6.Mashhad Univ Med Sci, Canc Mol Pathol Res Ctr, Ghaem Hosp, Sch Med, Mashhad, Iran
7.West China Hosp, Dept Dermatol, Chengdu, Peoples R China
8.Shandong Univ, Qilu Hosp, Jinan 250100, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Third Mil Med Univ, Southwest Hosp, Chongqing, Peoples R China
11.Fudan Univ, Huashan Hosp, Shanghai 200433, Peoples R China
12.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
13.First Hosp Wuhan, Wuhan, Peoples R China
14.Attikon Univ Hosp, Athens, Greece
15.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
16.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
推荐引用方式
GB/T 7714
Lu, X. -L.,Najafzadeh, M. J.,Dolatabadi, S.,et al. Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis[J]. PERSOONIA,2013,30:48-56.
APA Lu, X. -L..,Najafzadeh, M. J..,Dolatabadi, S..,Ran, Y. -P..,van den Ende, A. H. G. Gerrits.,...&de Hoog, G. S..(2013).Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis.PERSOONIA,30,48-56.
MLA Lu, X. -L.,et al."Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis".PERSOONIA 30(2013):48-56.
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