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学科主题: 临床医学
题名:
Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis
作者: Lu, X. -L.1,2,3,4; Najafzadeh, M. J.5,6; Dolatabadi, S.1; Ran, Y. -P.7; van den Ende, A. H. G. Gerrits1; Shen, Y. -N.3,4; Li, C. -Y.8; Xi, L. -Y.9; Hao, F.10; Zhang, Q. -Q.11; Li, R. -Y.12; Hu, Z. -M.13; Lu, G. -X.3,4; Wang, J. -J.9; Drogari-Apiranthitou, M.14; Klaassen, C.15; Meis, J. F.15; Hagen, F.15; Liu, W. -D.2,3,4; de Hoog, G. S.1,9,12,16
关键词: biodiversity ; chronic cutaneous infection ; epidemiology ; Mucor hiemalis ; Mucor irregularis ; Mucormycosis ; taxonomy
刊名: PERSOONIA
发表日期: 2013-06-01
DOI: 10.3767/003158513X665539
卷: 30, 页:48-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: RHIZOMUCOR-VARIABILIS ; EXTRACELLULAR LIPASE ; RHIZOPUS-ORYZAE ; IDENTIFICATION ; PHYCOMYCOSIS ; ZYGOMYCOSIS ; PHYLOGENY ; INFECTION ; ELEGANS ; WEHMER
英文摘要:

Mucormycosis usually presents as a progressive infection with significant angio-invasion. Mucormycosis due to Mucor irregularis (formerly Rhizomucor variabilis var. variabilis), however, is exceptional in causing chronic cutaneous infection in immunocompetent humans, ultimately leading to severe morbidity if left untreated. More than 90 % of the cases known to date were reported from Asia, mainly from China. The nearest neighbour of M. irregularis is the saprobic species M. hiemalis. The aim of this study was to evaluate the taxonomic position, epidemiology, and intra-and inter-species diversity of M. irregularis based on 21 strains (clinical n = 17) by multilocus analysis using ITS, LSU, RPB1 and RPB2 genes, compared to results of cluster analysis with amplified fragment length polymorphism (AFLP) data. By combining MLST and AFLP analyses, M. irregularis was found to be monophyletic with high bootstrap support, and consisted of five subgroups, which were not concordant in all partitions. It was thus confirmed that M. irregularis is a single species at 96.1-100 % ITS similarity and low recombination rates between populations. Some geographic structuring was noted with some localised populations, which may be explained by limited air-dispersal. The natural habitat of the species is likely to be in soil and decomposing plant material.

语种: 英语
所属项目编号: 11CDP009 ; 81101232
项目资助者: China Desk of KNAW project ; National Natural Sciences Foundation of China
WOS记录号: WOS:000317399800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67647
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, NL-3584 CT Utrecht, Netherlands
2.Dalian Med Univ, Dept Mycol, Dermatol Hosp Dalian, Dalian, Peoples R China
3.Chinese Acad Med Sci, Dept Mycol, Inst Dermatol, Nanjing, Jiangsu, Peoples R China
4.Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China
5.Mashhad Univ Med Sci, Dept Parasitol & Mycol, Ghaem Hosp, Sch Med, Mashhad, Iran
6.Mashhad Univ Med Sci, Canc Mol Pathol Res Ctr, Ghaem Hosp, Sch Med, Mashhad, Iran
7.West China Hosp, Dept Dermatol, Chengdu, Peoples R China
8.Shandong Univ, Qilu Hosp, Jinan 250100, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
10.Third Mil Med Univ, Southwest Hosp, Chongqing, Peoples R China
11.Fudan Univ, Huashan Hosp, Shanghai 200433, Peoples R China
12.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
13.First Hosp Wuhan, Wuhan, Peoples R China
14.Attikon Univ Hosp, Athens, Greece
15.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
16.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands

Recommended Citation:
Lu, X. -L.,Najafzadeh, M. J.,Dolatabadi, S.,et al. Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis[J]. PERSOONIA,2013,30:48-56.
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