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学科主题: 药学
题名:
Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry
作者: Guo, Xiao-Yu1; Liu, Dan2; Ye, Min1; Han, Jian1; Deng, Sa2; Ma, Xiao-Chi2; Zhao, YanYan2; Zhang, Baojing2; Shen, Xuan1; Che, Qing-Ming1
关键词: Ganoderic acid C2 ; Ganoderma lucidum ; Metabolites ; Pharmacokinetics ; HPLC-ESI-MS/MS ; LC-IT-TOF/MSn
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2013-03-05
DOI: 10.1016/j.jpba.2012.11.024
卷: 75, 页:64-73
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: LUCIDUM FR KARST ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; TOTAL TRITERPENOIDS ; CONSTITUENTS ; INHIBITION
英文摘要:

The metabolites and pharmacokinetics of ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis. It is the first time to report the metabolites and pharmacokinetics of GAC2. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30701078 ; 81274047 ; 81202589
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000314332500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67654
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.Dalian Med Univ, Sch Pharm, Dalian 116044, Peoples R China

Recommended Citation:
Guo, Xiao-Yu,Liu, Dan,Ye, Min,et al. Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,75:64-73.
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