IR@PKUHSC  > 北京大学药学院  > 天然药物学系
学科主题药学
Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry
Guo, Xiao-Yu1; Liu, Dan2; Ye, Min1; Han, Jian1; Deng, Sa2; Ma, Xiao-Chi2; Zhao, YanYan2; Zhang, Baojing2; Shen, Xuan1; Che, Qing-Ming1
关键词Ganoderic acid C2 Ganoderma lucidum Metabolites Pharmacokinetics HPLC-ESI-MS/MS LC-IT-TOF/MSn
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2013-03-05
DOI10.1016/j.jpba.2012.11.024
75页:64-73
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]LUCIDUM FR KARST ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; TOTAL TRITERPENOIDS ; CONSTITUENTS ; INHIBITION
英文摘要

The metabolites and pharmacokinetics of ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MSn), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis. It is the first time to report the metabolites and pharmacokinetics of GAC2. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30701078 ; 81274047 ; 81202589
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000314332500009
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67654
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
2.Dalian Med Univ, Sch Pharm, Dalian 116044, Peoples R China
推荐引用方式
GB/T 7714
Guo, Xiao-Yu,Liu, Dan,Ye, Min,et al. Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,75:64-73.
APA Guo, Xiao-Yu.,Liu, Dan.,Ye, Min.,Han, Jian.,Deng, Sa.,...&Che, Qing-Ming.(2013).Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,75,64-73.
MLA Guo, Xiao-Yu,et al."Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 75(2013):64-73.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guo, Xiao-Yu]的文章
[Liu, Dan]的文章
[Ye, Min]的文章
百度学术
百度学术中相似的文章
[Guo, Xiao-Yu]的文章
[Liu, Dan]的文章
[Ye, Min]的文章
必应学术
必应学术中相似的文章
[Guo, Xiao-Yu]的文章
[Liu, Dan]的文章
[Ye, Min]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。