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学科主题临床医学
Association Between Dosage Frequency and the Treatment Outcomes of Sildenafil in Young and Middle-aged Men With Erectile Dysfunction: A Chinese, Multicenter, Observational Study
Yang, Yi; Liu, Ruizhi; Jiang, Hui2; Hong, Kai; Zhao, Lianming; Tang, Wenhao; Mao, Jiaming
刊名UROLOGY
2015-07-01
DOI10.1016/j.urology.2015.03.011
86期:1页:62-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ON-DEMAND VARDENAFIL ; CARDIOVASCULAR-DISEASE ; 5 INHIBITORS ; RISK-FACTORS ; SAFETY ; EFFICACY ; HYPERTENSION ; TADALAFIL ; PHARMACOKINETICS ; PREVALENCE
英文摘要

OBJECTIVE To evaluate the correlation between the dosage frequency of sildenafil and its treatment outcomes in men with erectile dysfunction (ED).

METHODS Data were from a 4-week, multicenter, observational study of men (1699), between 18 and 60 years of age, with a clinical diagnosis of ED defined as the Sexual Health Inventory for Men (SHIM) score <= 21. The erectile function and quality of sexual life were evaluated at the baseline and the endpoint of sildenafil treatment (after 4 weeks) by using SHIM, Self-Esteem and Relationship Questionnaire, 36-Item Short Form Health Survey, Erection Hardness Score, and the global efficacy question.

RESULTS Nine hundred thirty-five patients were enrolled in the <= 1 weekly, 573 in the 2-3 weekly, and 158 in the 4-7 weekly dosage frequency cohorts. After 4 weeks of treatment, a higher dosage frequency of sildenafil was associated with a better SHIM, Self-Esteem and Relationship Questionnaire, and 36-Item Short Form Health Survey score improvement (all P <. 0001). Hyperlipidemia is a poor prognostic factor (odds ratio, 3.59; P =.04), whereas hypertension (odds ratio, 0.25; P <. 01) and coronary heart disease (odds ratio, 0.56; P=.05) are sensitive to sildenafil treatment.

CONCLUSION Higher dosage frequency of sildenafil is associated with a better improvement of sexual function and quality of life of men with ED, and the concomitant treatment of hyperlipidemia is recommended. (C) 2015 Elsevier Inc.

语种英语
WOS记录号WOS:000361902700018
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67658
Collection北京大学第三临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 3, Dept Urol, Beijing 100083, Peoples R China
2.Jilin Univ, Hosp 1, Reprod Med Ctr, Changchun 130023, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yi,Liu, Ruizhi,Jiang, Hui,et al. Association Between Dosage Frequency and the Treatment Outcomes of Sildenafil in Young and Middle-aged Men With Erectile Dysfunction: A Chinese, Multicenter, Observational Study[J]. UROLOGY,2015,86(1):62-67.
APA Yang, Yi.,Liu, Ruizhi.,Jiang, Hui.,Hong, Kai.,Zhao, Lianming.,...&Mao, Jiaming.(2015).Association Between Dosage Frequency and the Treatment Outcomes of Sildenafil in Young and Middle-aged Men With Erectile Dysfunction: A Chinese, Multicenter, Observational Study.UROLOGY,86(1),62-67.
MLA Yang, Yi,et al."Association Between Dosage Frequency and the Treatment Outcomes of Sildenafil in Young and Middle-aged Men With Erectile Dysfunction: A Chinese, Multicenter, Observational Study".UROLOGY 86.1(2015):62-67.
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