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Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats
Han, Y; Qin, J; Chang, XZ; Yang, ZX; Bu, DF; Du, JB
关键词hydrogen sulfide cystathionine b-synthase gamma-aminobutyric acid receptor febrile seizure
刊名NEUROSCIENCE RESEARCH
2005-10-01
DOI10.1016/j.neures.2005.07.002
53期:2页:216-219
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEUROMODULATOR ; PATHOGENESIS
英文摘要

Hydrogen sulfide (H2S) is recognized as a new neuromodulator in regulating various brain functions. Some of our recent studies showed that H2S alleviates the hippocampal damage induced by recurrent febrile seizures (FS). In the present study, we used a rat model of recurrent FS and found that sodium sulfhydrate (NaHS, a donor of H2S) down-regulated the expression of c-fos and increased the expression of gamma-aminobutyric acid B receptor subunits 1 (GABA(B)R1) and 2 (GABA(B)R2). Hydroxylamine (an inhibitor of cystathionine b-synthase) upregulated the expression of c-fos and down-regulated the expression of GABA(B)R2, but did not change the expression of GABA(B)R1. These results suggest that H2S plays a regulatory role through modulating GABA(B)R function in the pathogenesis of recurrent FS. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

语种英语
WOS记录号WOS:000232296800016
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67665
专题北京大学第一临床医学院_中心实验室
作者单位1.Peking Univ, Ctr Lab, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Han, Y,Qin, J,Chang, XZ,et al. Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats[J]. NEUROSCIENCE RESEARCH,2005,53(2):216-219.
APA Han, Y,Qin, J,Chang, XZ,Yang, ZX,Bu, DF,&Du, JB.(2005).Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats.NEUROSCIENCE RESEARCH,53(2),216-219.
MLA Han, Y,et al."Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats".NEUROSCIENCE RESEARCH 53.2(2005):216-219.
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