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学科主题: 临床医学
题名:
Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats
作者: Han, Y; Qin, J; Chang, XZ; Yang, ZX; Bu, DF; Du, JB
关键词: hydrogen sulfide ; cystathionine b-synthase ; gamma-aminobutyric acid ; receptor ; febrile seizure
刊名: NEUROSCIENCE RESEARCH
发表日期: 2005-10-01
DOI: 10.1016/j.neures.2005.07.002
卷: 53, 期:2, 页:216-219
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEUROMODULATOR ; PATHOGENESIS
英文摘要:

Hydrogen sulfide (H2S) is recognized as a new neuromodulator in regulating various brain functions. Some of our recent studies showed that H2S alleviates the hippocampal damage induced by recurrent febrile seizures (FS). In the present study, we used a rat model of recurrent FS and found that sodium sulfhydrate (NaHS, a donor of H2S) down-regulated the expression of c-fos and increased the expression of gamma-aminobutyric acid B receptor subunits 1 (GABA(B)R1) and 2 (GABA(B)R2). Hydroxylamine (an inhibitor of cystathionine b-synthase) upregulated the expression of c-fos and down-regulated the expression of GABA(B)R2, but did not change the expression of GABA(B)R1. These results suggest that H2S plays a regulatory role through modulating GABA(B)R function in the pathogenesis of recurrent FS. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

语种: 英语
WOS记录号: WOS:000232296800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67665
Appears in Collections:北京大学第一临床医学院_中心实验室_期刊论文

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作者单位: 1.Peking Univ, Ctr Lab, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Han, Y,Qin, J,Chang, XZ,et al. Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats[J]. NEUROSCIENCE RESEARCH,2005,53(2):216-219.
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