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Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence
Cao, Qingjiu2; Zang, Yufeng3; Zhu, Chaozhe3; Cao, Xiaohua2; Sun, Li2; Zhou, Xiaolin1; Wang, Yufeng2
关键词ADHD alerting phasic alerting intrinsic alerting attention event-related fMRI
刊名BRAIN RESEARCH
2008-07-11
DOI10.1016/j.brainres.2008.04.028
1219页:159-168
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]HYPERACTIVITY DISORDER ; SELECTIVE ATTENTION ; RESPONSE-INHIBITION ; WORKING-MEMORY ; FUNCTIONAL MRI ; BRAIN ; ADHD ; NETWORKS ; ACTIVATION ; ADOLESCENTS
英文摘要

Attention deficit/hyperactivity disorder (ADHD) is one of the most common but poorly understood developmental disorders in childhood. Although neuropsychological studies demonstrate that children with ADHD have attentional alerting deficits, the neurobiological bases of such deficits have not been examined extensively. in this study, by using functional magnetic resonance imaging (fMRI), we explored the neural correlates of intrinsic alertness and phasic alertness deficits in ADHD by comparing twelve boys with ADHD (13.4 +/- 1.7 years) with 13 age-matched normal controls (13.2 +/- 1.2 years) in a cued target detection task. Behaviorally, compared with the controls, the ADHD group showed a higher overall error rate and a larger reaction time variability in performing the task. At the neural level, children with ADHD showed less activation than the controls in frontal (middle and superior frontal gyrus), parietal (inferior parietal lobe, precuneus) and putamen regions. These results demonstrate that children with ADHD have deficits in alerting functions and these deficits are related to the abnormal activities in frontal and parietal regions subserving top-down attention control processes. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000257907000017
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被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67666
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
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Cao, Qingjiu,Zang, Yufeng,Zhu, Chaozhe,et al. Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence[J]. BRAIN RESEARCH,2008,1219:159-168.
APA Cao, Qingjiu.,Zang, Yufeng.,Zhu, Chaozhe.,Cao, Xiaohua.,Sun, Li.,...&Wang, Yufeng.(2008).Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence.BRAIN RESEARCH,1219,159-168.
MLA Cao, Qingjiu,et al."Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence".BRAIN RESEARCH 1219(2008):159-168.
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