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学科主题: 精神卫生
题名:
Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence
作者: Cao, Qingjiu2; Zang, Yufeng3; Zhu, Chaozhe3; Cao, Xiaohua2; Sun, Li2; Zhou, Xiaolin1; Wang, Yufeng2
关键词: ADHD ; alerting ; phasic alerting ; intrinsic alerting ; attention ; event-related fMRI
刊名: BRAIN RESEARCH
发表日期: 2008-07-11
DOI: 10.1016/j.brainres.2008.04.028
卷: 1219, 页:159-168
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: HYPERACTIVITY DISORDER ; SELECTIVE ATTENTION ; RESPONSE-INHIBITION ; WORKING-MEMORY ; FUNCTIONAL MRI ; BRAIN ; ADHD ; NETWORKS ; ACTIVATION ; ADOLESCENTS
英文摘要:

Attention deficit/hyperactivity disorder (ADHD) is one of the most common but poorly understood developmental disorders in childhood. Although neuropsychological studies demonstrate that children with ADHD have attentional alerting deficits, the neurobiological bases of such deficits have not been examined extensively. in this study, by using functional magnetic resonance imaging (fMRI), we explored the neural correlates of intrinsic alertness and phasic alertness deficits in ADHD by comparing twelve boys with ADHD (13.4 +/- 1.7 years) with 13 age-matched normal controls (13.2 +/- 1.2 years) in a cued target detection task. Behaviorally, compared with the controls, the ADHD group showed a higher overall error rate and a larger reaction time variability in performing the task. At the neural level, children with ADHD showed less activation than the controls in frontal (middle and superior frontal gyrus), parietal (inferior parietal lobe, precuneus) and putamen regions. These results demonstrate that children with ADHD have deficits in alerting functions and these deficits are related to the abnormal activities in frontal and parietal regions subserving top-down attention control processes. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000257907000017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67666
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

Recommended Citation:
Cao, Qingjiu,Zang, Yufeng,Zhu, Chaozhe,et al. Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence[J]. BRAIN RESEARCH,2008,1219:159-168.
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