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学科主题临床医学
Effects of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates
Wang, XL; Cui, YP; Tong, XM; Ye, HM; Li, S
刊名JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
2004-10-01
DOI10.1210/jc.2003-032027
89期:10页:4981-4985
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]INTRAUTERINE GROWTH-RETARDATION ; DEPENDENT DIABETES-MELLITUS ; REDUCED FETAL GROWTH ; BETA(3)-ADRENERGIC RECEPTOR ; BIRTH-WEIGHT ; RESISTANCE SYNDROME ; OBESITY ; ASSOCIATION ; MUTATION ; CHILDREN
英文摘要

To evaluate whether the Trp64Arg polymorphism in the beta3-adrenergic receptor (AR) gene is associated with decreased birth weight and might account for some of the association between birth weight and impaired insulin sensitivity, the beta3-AR genotype was assessed in 296 neonates of singleton pregnancies, including 76 neonates classified as small for gestational age (SGA) and 220 neonate classified as appropriate for gestational age (AGA). Fasting glucose and insulin levels were measured on d 3 after birth. The insulin levels and insulin-to-glucose ratio were significantly higher in the SGA group than in the AGA group. Frequency of the Trp64Arg allele was similar in the AGA and SGA groups (0.15 and 0.17, respectively). Moreover, when we adjusted for sex and gestational age, there was no significant difference in birth weight, fasting glucose, insulin levels, or insulin-to-glucose ratio between those with and without the mutation. However, in the SGA group, carriers of the Trp64Arg allele had significantly higher fasting insulin levels and insulin-to-glucose ratios than noncarriers (17.54 +/- 2.11 vs. 13.18 +/- 1.47 muIU/ml, P < 0.05; and 4.89 +/- 0.60 vs. 3.14 +/- 0.42, P < 0.05, respectively), whereas no association was detected for this polymorphism in the AGA group.

SGA is an important factor that predisposes to insulin resistance, and the Trp64Arg beta3-AR gene polymorphism may contribute to insulin resistance associated with reduced fetal growth.

语种英语
WOS记录号WOS:000224326300031
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67668
专题北京大学第三临床医学院_儿科
作者单位Third Hosp Peking Univ, Dept Pediat, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, XL,Cui, YP,Tong, XM,et al. Effects of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY &amp; METABOLISM,2004,89(10):4981-4985.
APA Wang, XL,Cui, YP,Tong, XM,Ye, HM,&Li, S.(2004).Effects of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,89(10),4981-4985.
MLA Wang, XL,et al."Effects of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 89.10(2004):4981-4985.
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