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学科主题: 临床医学
题名:
CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy
作者: Wang, Jun Jie1; Yuan, Hui Shu2; Li, Jin Na1; Jiang, Yu Liang1; Tian, Su Qing1; Yang, Rui Jie1
关键词: (125)I seed ; (103)Pd seed ; Implantation ; Brachytherapy ; Recurrent rectal carcinoma ; CT-guided
刊名: MEDICAL ONCOLOGY
发表日期: 2010-06-01
DOI: 10.1007/s12032-009-9227-7
卷: 27, 期:2, 页:421-429
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: COLORECTAL-CANCER ; ABDOMINOSACRAL RESECTION ; RADIATION-THERAPY ; SACRAL RESECTION ; BRACHYTHERAPY ; RADIOTHERAPY ; MANAGEMENT ; PROSTATE ; SURGERY ; DESIGN
英文摘要:

The recurrent carcinoma has been difficult to manage after surgery and radiotherapy, extensive resection of locally recurrent rectal cancer is associated with significant morbidity and mortality. Re-irradiation, even in combination with chemotherapy has shown very short survival. We assess the feasibility and efficacy of CT-guided interstitial permanent brachytherapy with (125)I or (103)Pd seeds for recurrent rectal cancer after multiple treatments. Fifteen patients with locally recurrent rectal carcinoma received (125)I or (103)Pd seed implants under CT guidance. The minimal peripheral dose of seed implants was 110-165 Gy (median 150 Gy). Two weeks after seed implantation, a 50 Gy of stereotactic radiotherapy was given to one patient; four patients received 2-4 cycles of chemotherapy. A median follow-up was 8 months (range 4-50 months). The duration of pain-free survival was 0-50 months (median 7 months). Local control was maintained for 3-50 months (median 7 months). The 1- and 2-year local controls were 16.2 and 8.1%, respectively. Eleven patients died: two (18.2%) of local recurrence, seven (63.6%) of local recurrence and metastases, and two (18.2%) of metastases. Four patients (26.7%) survived the median survival was 9 months. The 1- and 2-year actuarial overall survival rates were 42.9% and 10.7%, respectively. One patient (7.6%) experienced a grade 4 toxic event; there was no associated neuropathy. CT-guided radioactive seed implantation is feasible and safe as a salvage or palliative pain relief treatment for patients with recurrent rectal cancers after surgery and radiotherapy.

语种: 英语
WOS记录号: WOS:000277203200039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67670
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Jun Jie,Yuan, Hui Shu,Li, Jin Na,et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy[J]. MEDICAL ONCOLOGY,2010,27(2):421-429.
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