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学科主题: 临床医学
题名:
Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia
作者: Xu, Xue1; Liang, Mei-ying1; Wang, Jian-liu1; Chen, Shi2
关键词: Pregnancy ; SLE ; thrombocytopenia
刊名: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
发表日期: 2016-03-03
DOI: 10.3109/14767058.2015.1018169
卷: 29, 期:5, 页:789-794
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; MORTALITY ; MANAGEMENT ; ONSET
英文摘要:

Objective: To analyze the course of maternal diseases and compare pregnancy outcomes in patients with systemic lupus erythematosus (SLE)-associated thrombocytopenia to patients without.Methods: Medical charts of 77 pregnancies in 73 SLE patients were systematically reviewed. Patients were divided into two groups according to the presence or absence of thrombocytopenia. Patients who are new onset SLE during pregnancy were also been studied.Result: Thrombocytopenia was found in 18 (23.3%) of the pregnancies. SLE patients with thrombocytopenia during pregnancy had higher percentage of disease flaring (11/18 versus 14/59, p=0.003) and SLE-Pregnancy Disease Activity Index (7.896.192 versus 2.41 +/- 3.3.89, p=0.001) compared to patients without. Also, patients with thrombocytopenia had a higher percentage of pulmonary, cardiac and multiple organ system involvement. There was a statistically significant difference in preeclampsia and early onset hypertensive disorder induced before 34 weeks as well as the rate of live birth less than 34 weeks (33.3% versus 6.8%, p=0.003 & 38.9% versus 13.6%, p=0.018 & 16.7% versus 1.7%, p=0.038). Patients with thrombocytopenia suffered from higher rate of pregnancy loss (22.2% versus 3.4%, p=0.024) and neonatal death (33.3% versus 1.7%, p=0.000). In our study there were 17 patients with new-onset of SLE during pregnancy. The hematological system manifestation occurred in all of them and there was a significant increase in the incidence of thrombocytopenia (n=12, 70.6%).Conclusion: Thrombocytopenia in SLE during pregnancy indicates higher disease activity, severe organ damage, early onset preeclampsia and higher pregnancy loss.

语种: 英语
WOS记录号: WOS:000366323100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67671
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Xue,Liang, Mei-ying,Wang, Jian-liu,et al. Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2016,29(5):789-794.
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