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学科主题临床医学
Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia
Xu, Xue1; Liang, Mei-ying1; Wang, Jian-liu1; Chen, Shi2
关键词Pregnancy SLE thrombocytopenia
刊名JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
2016-03-03
DOI10.3109/14767058.2015.1018169
29期:5页:789-794
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; MORTALITY ; MANAGEMENT ; ONSET
英文摘要

Objective: To analyze the course of maternal diseases and compare pregnancy outcomes in patients with systemic lupus erythematosus (SLE)-associated thrombocytopenia to patients without.Methods: Medical charts of 77 pregnancies in 73 SLE patients were systematically reviewed. Patients were divided into two groups according to the presence or absence of thrombocytopenia. Patients who are new onset SLE during pregnancy were also been studied.Result: Thrombocytopenia was found in 18 (23.3%) of the pregnancies. SLE patients with thrombocytopenia during pregnancy had higher percentage of disease flaring (11/18 versus 14/59, p=0.003) and SLE-Pregnancy Disease Activity Index (7.896.192 versus 2.41 +/- 3.3.89, p=0.001) compared to patients without. Also, patients with thrombocytopenia had a higher percentage of pulmonary, cardiac and multiple organ system involvement. There was a statistically significant difference in preeclampsia and early onset hypertensive disorder induced before 34 weeks as well as the rate of live birth less than 34 weeks (33.3% versus 6.8%, p=0.003 & 38.9% versus 13.6%, p=0.018 & 16.7% versus 1.7%, p=0.038). Patients with thrombocytopenia suffered from higher rate of pregnancy loss (22.2% versus 3.4%, p=0.024) and neonatal death (33.3% versus 1.7%, p=0.000). In our study there were 17 patients with new-onset of SLE during pregnancy. The hematological system manifestation occurred in all of them and there was a significant increase in the incidence of thrombocytopenia (n=12, 70.6%).Conclusion: Thrombocytopenia in SLE during pregnancy indicates higher disease activity, severe organ damage, early onset preeclampsia and higher pregnancy loss.

语种英语
WOS记录号WOS:000366323100017
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67671
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Xue,Liang, Mei-ying,Wang, Jian-liu,et al. Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2016,29(5):789-794.
APA Xu, Xue,Liang, Mei-ying,Wang, Jian-liu,&Chen, Shi.(2016).Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia.JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,29(5),789-794.
MLA Xu, Xue,et al."Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia".JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 29.5(2016):789-794.
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