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学科主题: 临床医学
题名:
Should all endometrioid uterine cancer patients undergo systemic lymphadenectomy?
作者: Wang, Z. -Q.1; Wang, J. -L.1; Shen, D. -H.2; Li, X. -P.1; Wei, L. -H.1
关键词: Uterine cancer ; Endometrioid carcinoma ; Lymphadenectomy ; Staging ; Prognosis
刊名: EJSO
发表日期: 2013-04-01
DOI: 10.1016/j.ejso.2012.12.007
卷: 39, 期:4, 页:344-349
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: LYMPH-NODE METASTASIS ; PELVIC LYMPHADENECTOMY ; ADENOCARCINOMA
英文摘要:

Objective: To evaluate the potential benefits of systemic pelvic and para-aortic lymphadenectomy in endometrioid uterine cancer patients.

Methods: We conducted a retrospective study on 244 cases of endometrioid uterine cancer that involved surgery in the Center of Gynecologic Oncology, Peking University People′s Hospital, Beijing, from January 2000 to May 2008. We conducted staging for each case to ensure accordance with FIGO 2009 surgical staging criteria. Clinical data, including histology, age at diagnosis, surgical procedure, adjuvant therapy, date of death or last follow-up, and date and sites of recurrence were collected for each patient.

Results: Among 244 endometrioid uterine cancer patients, 207 cases (84.8%) underwent systemic pelvic lymphadenectomy. Among these cases, pelvic lymph nodes in 17 cases (8.2%) exhibited tumor metastasis. Systemic aortic lymphadenectomy was performed in 127 cases (52.0%) among 244 total patients. Five cases (3.9%) exhibited positive aortic lymph nodes, of which four exhibited positive pelvic lymph nodes. We investigated the impact of positive retroperitoneal lymph nodes on staging: 4 (4/161, 2.5%), 6 (6/29, 20.7%), 6 (6/35, 17.1%), 1 (1/8) and 1 (1/6) case changed to stage IIIc from stage Ia, Ib, II, IIIa, and IIIb, respectively. Tumor-free and overall survival did not differ between patients who underwent pelvic lymphadenectomy or not (P > 0.05). Tumor-free survival improved in stage Ib pelvic lymphadenectomy patients (P = 0.040); para-aortic lymph !E patient survival in all stages (P > 0.05).

Conclusion: Systemic lymphadenectomy, is not warranted in stage Ia endometrioid uterine cancer. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000316511800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67672
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Ctr Gynecol Oncol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Z. -Q.,Wang, J. -L.,Shen, D. -H.,et al. Should all endometrioid uterine cancer patients undergo systemic lymphadenectomy?[J]. EJSO,2013,39(4):344-349.
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