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Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen
Yang, Fan2; Zheng, Xiu-Jing2; Huo, Chang-Xin2; Wang, Yue2; Zhang, Ye1; Ye, Xin-Shan2
刊名ACS CHEMICAL BIOLOGY
2011-03-01
DOI10.1021/cb100287q
6期:3页:252-259
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]MUC1 GLYCOPEPTIDE ANTIGENS ; HUMORAL IMMUNE-RESPONSE ; T-CELL EPITOPE ; CONJUGATE VACCINE ; POLYSIALIC ACID ; CHEMOENZYMATIC SYNTHESIS ; SIALYL PHOSPHITE ; TUMOR-CELLS ; CANCER ; ANTIBODIES
英文摘要

The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigen′s, increase the chance to develop carbohydrate-based anticancer vaccines. However, carbohydrate antigens pose certain difficulties, and the major drawback is their weak immunogenicity. To tackle this problem, numerous structurally modified STn antigens were designed and synthesized in this work. These synthetic antigens were screened in vitro by using competitive ELISA method, and the antigens with positive response were conjugated to the protein carrier for vaccination. The vaccination results on mice showed that some fluorine containing modifications on the STn antigen can significantly increase the anti-STn IgG titers and improve the ratios of anti-STn IgG/IgM. The antisera can recognize the tumor cells expressing the native STn antigen.

语种英语
WOS记录号WOS:000288410700008
项目编号90713010 ; 20732001
资助机构National Natural Science Foundation of China
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67682
专题北京大学基础医学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_药物化学系
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Fan,Zheng, Xiu-Jing,Huo, Chang-Xin,et al. Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen[J]. ACS CHEMICAL BIOLOGY,2011,6(3):252-259.
APA Yang, Fan,Zheng, Xiu-Jing,Huo, Chang-Xin,Wang, Yue,Zhang, Ye,&Ye, Xin-Shan.(2011).Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen.ACS CHEMICAL BIOLOGY,6(3),252-259.
MLA Yang, Fan,et al."Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen".ACS CHEMICAL BIOLOGY 6.3(2011):252-259.
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