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学科主题: 基础医学
题名:
Functional studies using antibodies against orphanin FQ/nociceptin
作者: Tian, JH; Han, JS
关键词: orphanin FQ ; nociceptin ; antibody ; pain ; tolerance
刊名: PEPTIDES
发表日期: 2000-07-01
卷: 21, 期:7, 页:1047-1050
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ANTI-OPIOID PEPTIDE ; RAT SPINAL-CORD ; NOCICEPTIN RECEPTOR ; INDUCED ANALGESIA ; ELECTROACUPUNCTURE ANALGESIA ; PERIAQUEDUCTAL GRAY ; IN-VIVO ; FQ ; AGONIST ; < ; PHE(1)PSI(CH2-NH)GLY(2)> ; NOCICEPTIN-(1-13)-NH2
英文摘要:

Orphanin FQ/nociceptin (OFQ) is a recently discovered endogenous ligand for the novel opioid receptor-like receptor (ORL-1). There are numerous reports in the literature demonstrating paradoxical effects of exogenous OFQ on pain modulation. For example, OFQ produces a pronociceptive effect in the brain and an analgesic effect in the spinal cord. In order to better understand the physiological actions of OFQ, the present study focused on the pain-modulatory effect of endogenously released OFQ measured using antibody microinjection techniques. We found that electroacupuncture analgesia (EA) was increased by intracerebroventricular (i.c.v.) injection of an OFQ;antibody and decreased following intrathecal injection. Furthermore, i.c.v. OFQ-antibody partially reversed tolerance to both chronic morphine and chronic EA. These data suggest that endogenously released OFQ plays an important role in pain modulation, where pain sensitivity in the brain and spinal cord is increased and decreased, respectively. (C) 2000 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000089581300019
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67683
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Tian, JH,Han, JS. Functional studies using antibodies against orphanin FQ/nociceptin[J]. PEPTIDES,2000,21(7):1047-1050.
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