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学科主题基础医学
Functional studies using antibodies against orphanin FQ/nociceptin
Tian, JH; Han, JS
关键词orphanin FQ nociceptin antibody pain tolerance
刊名PEPTIDES
2000-07-01
21期:7页:1047-1050
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ANTI-OPIOID PEPTIDE ; RAT SPINAL-CORD ; NOCICEPTIN RECEPTOR ; INDUCED ANALGESIA ; ELECTROACUPUNCTURE ANALGESIA ; PERIAQUEDUCTAL GRAY ; IN-VIVO ; FQ ; AGONIST ; < ; PHE(1)PSI(CH2-NH)GLY(2)> ; NOCICEPTIN-(1-13)-NH2
英文摘要

Orphanin FQ/nociceptin (OFQ) is a recently discovered endogenous ligand for the novel opioid receptor-like receptor (ORL-1). There are numerous reports in the literature demonstrating paradoxical effects of exogenous OFQ on pain modulation. For example, OFQ produces a pronociceptive effect in the brain and an analgesic effect in the spinal cord. In order to better understand the physiological actions of OFQ, the present study focused on the pain-modulatory effect of endogenously released OFQ measured using antibody microinjection techniques. We found that electroacupuncture analgesia (EA) was increased by intracerebroventricular (i.c.v.) injection of an OFQ;antibody and decreased following intrathecal injection. Furthermore, i.c.v. OFQ-antibody partially reversed tolerance to both chronic morphine and chronic EA. These data suggest that endogenously released OFQ plays an important role in pain modulation, where pain sensitivity in the brain and spinal cord is increased and decreased, respectively. (C) 2000 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000089581300019
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67683
Collection北京大学基础医学院_神经生物学系
作者单位Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Tian, JH,Han, JS. Functional studies using antibodies against orphanin FQ/nociceptin[J]. PEPTIDES,2000,21(7):1047-1050.
APA Tian, JH,&Han, JS.(2000).Functional studies using antibodies against orphanin FQ/nociceptin.PEPTIDES,21(7),1047-1050.
MLA Tian, JH,et al."Functional studies using antibodies against orphanin FQ/nociceptin".PEPTIDES 21.7(2000):1047-1050.
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