IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer′s ring non-Hodgkin lymphoma
Yong, WB; Zhang, YT; Zheng, W; Wei, Y
关键词Walderyer&prime s ring non-Hodgkin lymphoma radiotherapy chemotherapy prognosis
刊名CHINESE MEDICAL JOURNAL
2000-02-01
113期:2页:148-150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To improve the prognosis and therapeutic efficacy of Waldeyer′s ring non-Hodgkin lymphoma (NHL-WR), combined radio-chemotherapy was used to treat the patients with NHL-WR and prognostic factors were analyzed.

Methods Ninety patients with stage I similar to IV NHL-WR were treated with combined radio-chemotherapy. 4000 cGy to 6000 cGy were given to Waldeyer′s ring structure and involved cervical nodes. Uninvolved low cervical nodes received 3000 cGy to 4000 cGy. The combination chemotherapy consisted of COPP ( cyclophosphamide [ CTX ], vincristine [VCR], procarbazine [PCZ], prednisone [PDN]) or CHOP (CTX, ADM, VCR and PDN). Univariate analysis was performed to determine the prognostic unfavorable factors.

Results Five-year overall survival rate was 69.7% for the whole group, and 83.2% for patients with stage I, II. In univariate analyses, over survival (OS) rates of the patients with low and intermediate grade (76.1%), with stage I, II (83.2%), without fever (75.2%) and with performance status (PS) 0, 1 (85.7%) were significantly better than those of the patients with high grade (53.0%), with stage III, IV (24.7%) with fever (38.5%), with PS2 (41.7%), PS 3, 4 (0.0%), respectively (P < 0.05).

Conclusions Combined radio-chemotherapy can improve the 5-year survival rate for the patients with NHL-WR, especially for stage I, II, patients. PS greater than or equal to 2, stage III, IV, fever and high grade histology were associated with unfavorable prognosis.

语种英语
WOS记录号WOS:000087114800017
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67688
Collection北京大学临床肿瘤学院_肿瘤内科
作者单位Beijing Med Univ, Dept Med Oncol, Beijing Canc Hosp, Sch Oncol, Beijing 100036, Peoples R China
Recommended Citation
GB/T 7714
Yong, WB,Zhang, YT,Zheng, W,et al. Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer&prime;s ring non-Hodgkin lymphoma[J]. CHINESE MEDICAL JOURNAL,2000,113(2):148-150.
APA Yong, WB,Zhang, YT,Zheng, W,&Wei, Y.(2000).Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer′s ring non-Hodgkin lymphoma.CHINESE MEDICAL JOURNAL,113(2),148-150.
MLA Yong, WB,et al."Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer′s ring non-Hodgkin lymphoma".CHINESE MEDICAL JOURNAL 113.2(2000):148-150.
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