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学科主题: 临床医学
题名:
Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer′s ring non-Hodgkin lymphoma
作者: Yong, WB; Zhang, YT; Zheng, W; Wei, Y
关键词: Walderyer&prime ; s ring non-Hodgkin lymphoma radiotherapy ; chemotherapy ; prognosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2000-02-01
卷: 113, 期:2, 页:148-150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Objective To improve the prognosis and therapeutic efficacy of Waldeyer′s ring non-Hodgkin lymphoma (NHL-WR), combined radio-chemotherapy was used to treat the patients with NHL-WR and prognostic factors were analyzed.

Methods Ninety patients with stage I similar to IV NHL-WR were treated with combined radio-chemotherapy. 4000 cGy to 6000 cGy were given to Waldeyer′s ring structure and involved cervical nodes. Uninvolved low cervical nodes received 3000 cGy to 4000 cGy. The combination chemotherapy consisted of COPP ( cyclophosphamide [ CTX ], vincristine [VCR], procarbazine [PCZ], prednisone [PDN]) or CHOP (CTX, ADM, VCR and PDN). Univariate analysis was performed to determine the prognostic unfavorable factors.

Results Five-year overall survival rate was 69.7% for the whole group, and 83.2% for patients with stage I, II. In univariate analyses, over survival (OS) rates of the patients with low and intermediate grade (76.1%), with stage I, II (83.2%), without fever (75.2%) and with performance status (PS) 0, 1 (85.7%) were significantly better than those of the patients with high grade (53.0%), with stage III, IV (24.7%) with fever (38.5%), with PS2 (41.7%), PS 3, 4 (0.0%), respectively (P < 0.05).

Conclusions Combined radio-chemotherapy can improve the 5-year survival rate for the patients with NHL-WR, especially for stage I, II, patients. PS greater than or equal to 2, stage III, IV, fever and high grade histology were associated with unfavorable prognosis.

语种: 英语
WOS记录号: WOS:000087114800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67688
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: Beijing Med Univ, Dept Med Oncol, Beijing Canc Hosp, Sch Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Yong, WB,Zhang, YT,Zheng, W,et al. Prognostic factors and therapeutic efficacy of combined radio-chemotherapy in Waldeyer&prime;s ring non-Hodgkin lymphoma[J]. CHINESE MEDICAL JOURNAL,2000,113(2):148-150.
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