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学科主题: 临床医学
题名:
Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent
作者: Ma, Xiaowei1,2; Fu, Yongnan1,2,3; Xiao, Han1,2; Song, Yao1,2; Chen, Ruifei1,2; Shen, Jing1,2; An, Xiangbo1,2; Shen, Qiang1,2; Li, Zijian1,2; Zhang, Youyi1,2
刊名: PLOS ONE
发表日期: 2015-06-12
DOI: 10.1371/journal.pone.0129971
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; LEFT-VENTRICULAR HYPERTROPHY ; VEIN ENDOTHELIAL-CELLS ; KAPPA-B ACTIVATION ; OXIDATIVE STRESS ; HEART-FAILURE ; NAD(P)H OXIDASE ; SKELETAL-MUSCLE ; UP-REGULATION ; EXPRESSION
英文摘要:

Regular exercise can protect the heart against external stimuli, but the mechanism is not well understood. We determined the role of adenosine monophosphate-activated protein kinase (AMPK) in regulating swimming exercise-mediated cardiac protection against beta-adrenergic receptor overstimulation with isoproterenol (ISO) in mice. Ten-week-old AMPK alpha 2(+/+) and AMPK alpha 2-knockout (AMPK alpha 2(-/-)) littermates were subjected to 4 weeks of swimming training (50 min daily, 6 days a week) or housed under sedentary conditions. The mice received daily subcutaneous injection of ISO (5 mg/kg/d), a nonselective beta-adrenergic receptor agonist, during the last 2 weeks of swimming training. Swimming training alleviated ISO-induced cardiac fibrosis in AMPK alpha 2(+/+) mice but not AMPK alpha 2(-/-) mice. Swimming training activated cardiac AMPK in AMPK alpha 2(+/+) mice. Furthermore, swimming training attenuated ISO-induced production of reactive oxygen species (ROS) and expression of NADPH oxidase and promoted the expression of antioxidant enzymes in AMPK alpha 2(+/+) mice but not AMPK alpha 2(-/-) mice. In conclusion, swimming training attenuates ISO-induced cardiac fibrosis by inhibiting the NADPH oxidase-ROS pathway mediated by AMPK activation. Our findings provide a new mechanism for the cardioprotective effects of exercise.

语种: 英语
所属项目编号: 81030001 ; 2012CB51800
项目资助者: Natural Science Foundation of China (NSFC) ; National Key Basic Research Program of the People&prime ; s Republic of China
WOS记录号: WOS:000356327000127
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67689
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China
2.Nanchang Univ, Affiliated Hosp 1, Nanchang, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med,Minist Hlth,Minist Educ, Key Lab Mol Cardiovasc Sci,Key Lab Cardiovasc Mol, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Xiaowei,Fu, Yongnan,Xiao, Han,et al. Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent[J]. PLOS ONE,2015,10(6).
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