IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent
Ma, Xiaowei1,2; Fu, Yongnan1,2,3; Xiao, Han1,2; Song, Yao1,2; Chen, Ruifei1,2; Shen, Jing1,2; An, Xiangbo1,2; Shen, Qiang1,2; Li, Zijian1,2; Zhang, Youyi1,2
刊名PLOS ONE
2015-06-12
DOI10.1371/journal.pone.0129971
10期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Natural Science Foundation of China (NSFC) ; National Key Basic Research Program of the People&prime ; s Republic of China ; Natural Science Foundation of China (NSFC) ; National Key Basic Research Program of the People&prime ; s Republic of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACTIVATED PROTEIN-KINASE ; LEFT-VENTRICULAR HYPERTROPHY ; VEIN ENDOTHELIAL-CELLS ; KAPPA-B ACTIVATION ; OXIDATIVE STRESS ; HEART-FAILURE ; NAD(P)H OXIDASE ; SKELETAL-MUSCLE ; UP-REGULATION ; EXPRESSION
英文摘要

Regular exercise can protect the heart against external stimuli, but the mechanism is not well understood. We determined the role of adenosine monophosphate-activated protein kinase (AMPK) in regulating swimming exercise-mediated cardiac protection against beta-adrenergic receptor overstimulation with isoproterenol (ISO) in mice. Ten-week-old AMPK alpha 2(+/+) and AMPK alpha 2-knockout (AMPK alpha 2(-/-)) littermates were subjected to 4 weeks of swimming training (50 min daily, 6 days a week) or housed under sedentary conditions. The mice received daily subcutaneous injection of ISO (5 mg/kg/d), a nonselective beta-adrenergic receptor agonist, during the last 2 weeks of swimming training. Swimming training alleviated ISO-induced cardiac fibrosis in AMPK alpha 2(+/+) mice but not AMPK alpha 2(-/-) mice. Swimming training activated cardiac AMPK in AMPK alpha 2(+/+) mice. Furthermore, swimming training attenuated ISO-induced production of reactive oxygen species (ROS) and expression of NADPH oxidase and promoted the expression of antioxidant enzymes in AMPK alpha 2(+/+) mice but not AMPK alpha 2(-/-) mice. In conclusion, swimming training attenuates ISO-induced cardiac fibrosis by inhibiting the NADPH oxidase-ROS pathway mediated by AMPK activation. Our findings provide a new mechanism for the cardioprotective effects of exercise.

语种英语
所属项目编号81030001 ; 2012CB51800
资助者Natural Science Foundation of China (NSFC) ; National Key Basic Research Program of the People&prime ; s Republic of China ; Natural Science Foundation of China (NSFC) ; National Key Basic Research Program of the People&prime ; s Republic of China
WOS记录号WOS:000356327000127
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67689
专题北京大学第三临床医学院
作者单位1.Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China
2.Nanchang Univ, Affiliated Hosp 1, Nanchang, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med,Minist Hlth,Minist Educ, Key Lab Mol Cardiovasc Sci,Key Lab Cardiovasc Mol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiaowei,Fu, Yongnan,Xiao, Han,et al. Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent[J]. PLOS ONE,2015,10(6).
APA Ma, Xiaowei.,Fu, Yongnan.,Xiao, Han.,Song, Yao.,Chen, Ruifei.,...&Zhang, Youyi.(2015).Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent.PLOS ONE,10(6).
MLA Ma, Xiaowei,et al."Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent".PLOS ONE 10.6(2015).
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