|Efficacy and Tolerability of Long-Acting Nifedipine GITS/OROS Monotherapy or Combination Therapy in Hypertensive Patients Results of a 12-Week International, Prospective, Multicentre, Observational Study|
|Ueng, Kwo-Chang1; Sun Ningling2; Abd El Maksod3; Hung, Kuan-Yu4; Yin Yuehui5|
|刊名||CLINICAL DRUG INVESTIGATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Pharmacology & Pharmacy|
|研究领域[WOS]||Pharmacology & Pharmacy|
|关键词[WOS]||CONTROLLED-RELEASE NIFEDIPINE ; BLOOD-PRESSURE ; CARDIOVASCULAR-DISEASE ; POSTMARKETING SURVEILLANCE ; CHINESE PATIENTS ; ANGINA-PECTORIS ; ASIA-PACIFIC ; GITS ; MANAGEMENT ; SYSTEM|
Background: Achieving the maximum reduction in cardiovascular morbidity and mortality is the primary goal of blood pressure (BP) control. Current guidelines recommend several antihypertensive classes as first-line therapy for this purpose but the decision on which agent/s to use will likely be based upon the treating physician′s clinical experience. Observational studies provide a useful way of ascertaining the efficacy and tolerability of an antihypertensive in a real-life clinical setting.
Objective: The aim of this observational study was to determine the efficacy, tolerability and physician/patient satisfaction with long-acting nifedipine (gastrointestinal therapeutic system [GITS]/osmotic-controlled release oral delivery system [OROS]) in a large multinational cohort of hypertensive patients.
Methods: This observational study was conducted in adults (aged >= 18 years) with previously untreated or treated hypertension. The decision to prescribe nifedipine 30 or 60 mg once daily was made by the treating physician. Patients then attended up to three clinic visits any time over a 12-week period when medication could be up- or down-titrated or switched. The mean reduction in systolic BP (SBP)/diastolic BP (DBP) from first visit and whether target BP (<140/<90 mmHg or <130/<80 mmHg [for patients with diabetes mellitus]) had been achieved were recorded at the final visit and stratified according to hypertension grade and presence of cardiovascular risk factors. Subjective assessment of efficacy was reported by physicians and patients. All adverse events and their possible relationship to study drug were recorded. All assessments were performed on patients who received at least one dose of nifedipine GITS/OROS.
Results: A total of 14 344 patients received nifedipine GITS/OROS treatment (58.7% male; 77.7% non-diabetic; mean age 57.5 years); 14 266 had at least one follow-up visit over a mean 10.2-week period, and 8000 patients had three visits over a mean 12-week period. Initially, 12 826 (89.4%) patients received nifedipine 30 mg, and 6912 patients (48.2%) overall received concomitant antihypertensive agents. The overall mean reduction in SBP/DBP was -27.7/-14.1 mmHg; BP reduction was linked to hypertension grade, age, the presence of five or more cardiovascular risk factors, and prior treatment. Target BP was achieved in 2485/7432 patients (33.4%) receiving nifedipine GITS/OROS monotherapy and in 1751/6912 (25.3%) receiving combination therapy (i.e. GITS/OROS plus any other antihypertensive agent). Non-diabetic patients with moderate (n = 3413) and high (n=1138) risk reached their target BP goal in 62.5% and 54.2% of cases, respectively; the corresponding values in diabetic patients (moderate-added risk n = 8; high-added risk n = 684) were 75.0% and 54.8%, respectively. A total of 229 patients (1.6%) reported experiencing 286 adverse events. Physician/patient satisfaction with treatment was high.
Conclusion: Long-acting nifedipine GITS/OROS, alone or in combination with other antihypertensive agents, provides effective and well tolerated treatment of hypertension in a broad spectrum of patients routinely seen in day-to-day clinical practice.
|资助机构||Bayer Schering Pharma, Leverkusen, Germany|
|作者单位||1.Dr Erfan & Bagedo Gen Hosp, Jeddah, Saudi Arabia|
2.Chung Shan Med Univ, Inst Med, Sch Med, Chung Shan Med Univ Hosp,Dept Internal Med, Taichung 402, Taiwan
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Clin Dept Internal Med, Taipei 10764, Taiwan
5.Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China
|Ueng, Kwo-Chang,Sun Ningling,Abd El Maksod,et al. Efficacy and Tolerability of Long-Acting Nifedipine GITS/OROS Monotherapy or Combination Therapy in Hypertensive Patients Results of a 12-Week International, Prospective, Multicentre, Observational Study[J]. CLINICAL DRUG INVESTIGATION,2011,31(9):631-642.|
|APA||Ueng, Kwo-Chang,Sun Ningling,Abd El Maksod,Hung, Kuan-Yu,&Yin Yuehui.(2011).Efficacy and Tolerability of Long-Acting Nifedipine GITS/OROS Monotherapy or Combination Therapy in Hypertensive Patients Results of a 12-Week International, Prospective, Multicentre, Observational Study.CLINICAL DRUG INVESTIGATION,31(9),631-642.|
|MLA||Ueng, Kwo-Chang,et al."Efficacy and Tolerability of Long-Acting Nifedipine GITS/OROS Monotherapy or Combination Therapy in Hypertensive Patients Results of a 12-Week International, Prospective, Multicentre, Observational Study".CLINICAL DRUG INVESTIGATION 31.9(2011):631-642.|
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