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学科主题: 临床医学
题名:
Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease
作者: Yu, J.1; Zhang, Z.2; Li, Z.1; Feng, X.1; He, L.1; Liu, S.1; Mao, J.1; Wang, G.1; Wang, X.1,3,4
关键词: CORONARY ARTERY DISEASE ; DIABETES MELLITUS ; ENDOTHELIAL FUNCTION ; ROSIGLITAZONE ; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-gamma (PPAR gamma) AGONIST ; CORONARY FLOW VELOCITY RESERVE
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2010
卷: 38, 期:1, 页:86-94
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; NONDIABETIC PATIENTS ; INFLAMMATORY MARKERS ; DENSITY-LIPOPROTEIN ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; PIOGLITAZONE ; ATHEROSCLEROSIS ; ROSIGLITAZONE ; EXPRESSION
英文摘要:

The aim of this study was to assess the effect of rosiglitazone on endothelial function of the coronary arteries and on plasma levels of inflammatory markers in diabetic patients with coronary artery disease (CAD). Fifty-six patients with type 2 diabetes and CAD were randomized to receive either rosiglitazone (4 mg/day) or a control for 12 weeks. The coronary flow velocity reserve (CFVR) was assessed using transthoracic Doppler echocardiography at baseline and after 12 weeks. After 12 weeks of rosiglitazone treatment, plasma levels of C-reactive protein were significantly decreased and the median CFVR was significantly increased compared with baseline levels and compared with the control group. These results suggest that, in addition to its beneficial metabolic effects, rosiglitazone, via its anti-inflammatory effects, may improve endothelial function of the coronary arteries in patients with diabetes and CAD.

语种: 英语
所属项目编号: 2006CB503802 ; 30730042 ; 30770873
项目资助者: Major National Basic Research Program of China ; Chinese National Natural Science Foundation
WOS记录号: WOS:000276789900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67693
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiosurg Med, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Physiol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yu, J.,Zhang, Z.,Li, Z.,et al. Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2010,38(1):86-94.
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