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Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease
Yu, J.1; Zhang, Z.2; Li, Z.1; Feng, X.1; He, L.1; Liu, S.1; Mao, J.1; Wang, G.1; Wang, X.1,3,4
关键词CORONARY ARTERY DISEASE DIABETES MELLITUS ENDOTHELIAL FUNCTION ROSIGLITAZONE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-gamma (PPAR gamma) AGONIST CORONARY FLOW VELOCITY RESERVE
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2010
38期:1页:86-94
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]SMOOTH-MUSCLE-CELLS ; NONDIABETIC PATIENTS ; INFLAMMATORY MARKERS ; DENSITY-LIPOPROTEIN ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; PIOGLITAZONE ; ATHEROSCLEROSIS ; ROSIGLITAZONE ; EXPRESSION
英文摘要

The aim of this study was to assess the effect of rosiglitazone on endothelial function of the coronary arteries and on plasma levels of inflammatory markers in diabetic patients with coronary artery disease (CAD). Fifty-six patients with type 2 diabetes and CAD were randomized to receive either rosiglitazone (4 mg/day) or a control for 12 weeks. The coronary flow velocity reserve (CFVR) was assessed using transthoracic Doppler echocardiography at baseline and after 12 weeks. After 12 weeks of rosiglitazone treatment, plasma levels of C-reactive protein were significantly decreased and the median CFVR was significantly increased compared with baseline levels and compared with the control group. These results suggest that, in addition to its beneficial metabolic effects, rosiglitazone, via its anti-inflammatory effects, may improve endothelial function of the coronary arteries in patients with diabetes and CAD.

语种英语
WOS记录号WOS:000276789900010
项目编号2006CB503802 ; 30730042 ; 30770873
资助机构Major National Basic Research Program of China ; Chinese National Natural Science Foundation
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67693
专题北京大学第三临床医学院_心血管内科
北京大学第三临床医学院_妇产科
北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Hosp 3, Dept Cardiovasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiosurg Med, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Physiol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, J.,Zhang, Z.,Li, Z.,et al. Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2010,38(1):86-94.
APA Yu, J..,Zhang, Z..,Li, Z..,Feng, X..,He, L..,...&Wang, X..(2010).Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,38(1),86-94.
MLA Yu, J.,et al."Peroxisome Proliferator-activated Receptor-gamma (PPAR gamma) Agonist Improves Coronary Artery Endothelial Function in Diabetic Patients with Coronary Artery Disease".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 38.1(2010):86-94.
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