IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer
Zhu, XH; Mao, ZB; Na, YQ; Guo, YL; Wang, XH; Xin, DQ
关键词PTTG1 prostate cancer
刊名ANTICANCER RESEARCH
2006-03-01
26期:2A页:1253-1259
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]EXPRESSION ; IDENTIFICATION ; PROGRESSION
英文摘要

Recently, the pituitary tumor transforming gene I (PTTG1) has been suggested to be an oncogene. To investigate whether PTTG1 plays a positive role in the pathogenesis of prostate cancer, PTTG1 protein expression was examined in prostate tissue samples by immunohistochemistry PTTG1 expression was detected in a high percentage of prostate cancer tissues (34141, 82.9%), but to a much lesser extent in nonmalignant tissues (5/14, 35.7%). To further confirm these results, the expression vectors containing either the PTTG1 or antisense-PTTG1 gene were transfected into a prostate cancer cell line, LNCaP, and the cell proliferation rate was studied, as well as tumorigenicity in the LNCaP cells expressing different levels of the PTTG1 protein. Ectopic PTTG1 gene expression promoted prostate cancer cell proliferation and tumorigenesis both in vitro and in nude mice. In contrast, down-regulation of PTTG1 led to suppression of tumor cell growth. These results suggest that PTTG1 may be a potential prognostic marker for prostate cancer and that the down-regulation of PTTG1 may be a therapeutic target in the suppression of prostate cancer growth.

语种英语
WOS记录号WOS:000236674800059
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67698
Collection北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Ctr Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
4.Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Zhu, XH,Mao, ZB,Na, YQ,et al. Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer[J]. ANTICANCER RESEARCH,2006,26(2A):1253-1259.
APA Zhu, XH,Mao, ZB,Na, YQ,Guo, YL,Wang, XH,&Xin, DQ.(2006).Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer.ANTICANCER RESEARCH,26(2A),1253-1259.
MLA Zhu, XH,et al."Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer".ANTICANCER RESEARCH 26.2A(2006):1253-1259.
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