北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科  > 期刊论文
学科主题: 临床医学
题名:
Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer
作者: Zhu, XH; Mao, ZB; Na, YQ; Guo, YL; Wang, XH; Xin, DQ
关键词: PTTG1 ; prostate cancer
刊名: ANTICANCER RESEARCH
发表日期: 2006-03-01
卷: 26, 期:2A, 页:1253-1259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EXPRESSION ; IDENTIFICATION ; PROGRESSION
英文摘要:

Recently, the pituitary tumor transforming gene I (PTTG1) has been suggested to be an oncogene. To investigate whether PTTG1 plays a positive role in the pathogenesis of prostate cancer, PTTG1 protein expression was examined in prostate tissue samples by immunohistochemistry PTTG1 expression was detected in a high percentage of prostate cancer tissues (34141, 82.9%), but to a much lesser extent in nonmalignant tissues (5/14, 35.7%). To further confirm these results, the expression vectors containing either the PTTG1 or antisense-PTTG1 gene were transfected into a prostate cancer cell line, LNCaP, and the cell proliferation rate was studied, as well as tumorigenicity in the LNCaP cells expressing different levels of the PTTG1 protein. Ectopic PTTG1 gene expression promoted prostate cancer cell proliferation and tumorigenesis both in vitro and in nude mice. In contrast, down-regulation of PTTG1 led to suppression of tumor cell growth. These results suggest that PTTG1 may be a potential prognostic marker for prostate cancer and that the down-regulation of PTTG1 may be a therapeutic target in the suppression of prostate cancer growth.

语种: 英语
WOS记录号: WOS:000236674800059
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67698
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Ctr Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
4.Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhu, XH,Mao, ZB,Na, YQ,et al. Significance of pituitary tumor transforming gene 1 (PTTG1) in prostate cancer[J]. ANTICANCER RESEARCH,2006,26(2A):1253-1259.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhu, XH]'s Articles
[Mao, ZB]'s Articles
[Na, YQ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhu, XH]‘s Articles
[Mao, ZB]‘s Articles
[Na, YQ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace